Matsumoto, Japan – Early detection and treatment of hereditary transthyretin-related amyloidosis via genetic counseling are crucial. Yet, not all at-risk individuals seek genetic counseling, and management for presymptomatic carriers remains unclear. To tackle these knowledge gaps, a research team from Japan conducted a retrospective study on over 200 people who...
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Matsumoto, Japan – Metabolic dysfunction–associated steatotic liver disease (MASLD) is a well-known risk factor for colorectal cancer (CRC). MASLD has emerged as a heterogenous disease tightly linked to metabolic dysfunction and has been redefined under the umbrella term ‘steatotic liver disease’ (SLD). However, CRC risk variations across different SLD subgroups remain unknown....
Compared with standard whole-body magnetic resonance imaging (WBMRI), a short WBMRI protocol may reduce the length of MRI tests, while maintaining high sensitivity and specificity, among patients with multiple myeloma (MM) undergoing diagnostic testing, according to research published in Diagnostics. MM is the second-most common hematologic cancer, following non-Hodgkin lymphomas, and...
Chengdu, China – Prof. Changyang Gong’s team (Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University) wrote this review, in which Dr. Xianzhou Huang leads most of the research. Rapid growth in nanoparticles as delivery systems holds vast promise to promote therapeutic approaches...
Montreal , Canada – UdeM’s Stéphanie Forté and co-researchers in Canada and Brazil have shown how people with sickle cell disease or sickle cell trait have a higher chance of dying from COVID-19 than the general population. Patients with sickle cell disease and carriers of the sickle cell trait, often...
SEOUL, South Korea — SillaJen, Inc. (KOSDAQ: 215600) has submitted CSR to the US FDA on 06 Feb 2024 for REN026, a phase 1b/2a dose escalation and safety/efficacy evaluation study of Pexa-Vec in combination with cemiplimab in patients with metastatic or unresectable renal cell carcinoma (RCC). The study demonstrated an...
Bochum, Germany – Diabetes often remains undetected until it has already damaged organs or nerves. This is partly due to the fact that diagnosis at an early stage is time-consuming and difficult. An international team of researchers headed by Associate Professor Dr. Johannes Dietrich from the Department of Medicine I...
San Diego, Calif. – Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen treatments. Identifying candidate drugs for further optimization typically involves thousands of...
Pittsburgh, Pennsylvania – In Lambert-Eaton myasthenic syndrome (LEMS), patients’ immune systems attack a critical nerve cell protein, causing muscle weakness and degeneration. But not always — some patients lack antibodies to this protein, the calcium channel. Using the MCell simulation software developed in collaboration with the Pittsburgh Supercomputing Center (PSC),...
Baltimore, Maryland – A single dose of the typhoid conjugate vaccine, Typbar TCV®, provides lasting efficacy in preventing typhoid fever in children ages 9 months to 12 years old, according to a new study conducted by researchers at University of Maryland School of Medicine’s (UMSOM) Center for Vaccine Development and...