SAN DIEGO, CA ― The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to results of the Phase II SUMMIT trial reported by researchers at The University of Texas MD...
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Bonn, Germany – Under the leadership of PD Dr. Niklas Klümper, Assistant Physician at the Department of Urology at the University Hospital Bonn (UKB) and Clinician Scientist of the BMBF-funded ACCENT program and PD Dr. Markus Eckstein, senior physician at the Institute of Pathology at the Uniklinikum Erlangen of the...
BUFFALO, NY – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 1, entitled, “Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis.” Research has demonstrated that...
This study is led by Prof. Lixiang Xue (Cancer Center of Peking University Third Hospital Center of Basic Medical Research, Peking University Third Hospital). In ovarian cancer, the abnormal expression of various metabolic enzymes in the metabolism of polyunsaturated fatty acids (PUFA) is involved in the development of tumor and...
DALLAS, TX — Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a clinical-stage gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of severe monogenic diseases of the central nervous system (CNS), today announced updates to its TSHA-102 program in clinical evaluation for the treatment of Rett...
A research team led by a University of Iowa investigator has generated DNA-like compounds that effectively inhibit the cells responsible for systemic lupus erythematosus — the most common and serious form of lupus. There currently is no cure for this chronic autoimmune condition that damages the skin, joints and internal...
SAN ANTONIO, Texas — The 50 families stretch from the Netherlands and the United Kingdom to the United States and China. Each family has a child who is paralyzed from a mutation in a single gene named Contactin-Associated Protein 1 (Cntnap1). The children are locked inside their bodies, unable to...
A randomized trial found that video-based, telehealth-delivered exercise and weight loss programs with online educational support improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention that included a dietary component conferred modest additional pain and function benefits and led to substantial weight loss. The...
São Paulo, Brazil. In recent years, physicians and scientists in parts of Brazil where visceral leishmaniasis (VL) is endemic have seen rising numbers of cases of co-infection by Leishmania infantum and Crithidia, also a protozoan but hitherto believed to be a mosquito parasite that cannot infect humans or other mammals. Accurate diagnosis...
Tallinn, Estonia – Surprisingly high fraction of infertile men presenting congenital testicular maldescent, cryptorchidism, were revealed as undiagnosed cases of congenital RASopathy syndromes, as stated in a recent publication by researchers from the University of Tartu and the Andrology Clinic of Tartu University Hospital. Approximately 2-4% of male newborns are...