INDIANAPOLIS — Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools—previously developed to analyze brains of patients in the clinic—to investigate Alzheimer’s disease progression in preclinical animal models. The research team, led by Evgeny Chumin, PhD, a postdoctoral research fellow in the College of...
research News
INDIANAPOLIS, USA – Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to new treatments for people with Duchenne muscular dystrophy (DMD). The study, recently published in Nature Communications, demonstrates the effectiveness of their novel gene therapy technology in improving muscle tissue and overall strength in mice models with Duchenne muscular dystrophy. Duchenne muscular dystrophy is...
WASHINGTON – A study involving 678 individuals who apply pesticides, culled from a U.S. Agricultural Health Study of over 50,000 farmers, recently found that exposure to certain pesticides doubles one’s risk of developing an abnormal blood condition called MGUS (monoclonal gammopathy of undetermined significance) compared with individuals in the general...
WASHINGTON – Individuals living with severe sickle cell disease (SCD) are highly interested in new, potentially curative gene therapy treatments and are willing to accept associated risks for a chance at a cure, according to a study published today in Blood Advances. SCD is an inherited red blood cell disorder...
Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand...
FRANKFURT, Germany – Wanderlust and climate change mean that viruses transmitted by mosquitoes are increasingly spreading across Europe. The class of flaviviruses, which comprises the dengue, Zika, West Nile and yellow fever viruses, cause serious neurological diseases for which only insufficiently effective vaccines and no specific treatment options currently exist....
BERLIN, Germany – Infection with the stomach bacterium Helicobacter pylori could increase the risk of developing Alzheimer’s disease: In people over the age of 50, the risk following a symptomatic infection can be an average of 11 percent higher, and even more about ten years after the infection, at 24...
DUARTE, Calif. – In a breakthrough for human milk science, researchers at City of Hope, Los Angeles, have dosed the first patient in a Phase 2a clinical trial evaluating a novel therapy for blood cancer patients undergoing allogeneic hematopoietic stem cell transplantation. The investigational treatment, PBCLN-010 in combination with PBCLN-014,...
BEIJING, China — InnoCare Pharma, a commercial-stage biotech company, announced today that the U.S. Food and Drug Administration (FDA) has cleared the Investigational New Drug (IND) application for the Company’s B-cell lymphoma-2 (BCL2) inhibitor, ICP-248. This is InnoCare’s fifth innovative drug to enter the clinical stage in the USA. This...
DURHAM, N.C. — For too long, cancer treatment has been a double-edged sword – the very treatments designed to kill cancer cells often wrought havoc on healthy ones too. But a new study published online Oct. 30 in Immunity, a Cell Press journal, unveils an approach to cancer treatment that...