BUFFALO, N.Y. — A viral gene therapy developed by University at Buffalo researchers has reversed some brain abnormalities in infant mice with FOXG1 syndrome, a significant step toward one day treating children with this severe neurodevelopmental disorder. This mediated delivery of the FOXG1 gene via adeno-associated virus 9 (AAV9) is...
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BUFFALO, N.Y. — More than a decade ago, physicians around the world began reporting cases due to a new hypervirulent strain of Klebsiella pneumoniae, which could infect and severely sicken otherwise healthy people. Thomas A. Russo, MD, at the University at Buffalo and the VA Western New York Healthcare System...
London, UK – Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice co-led by a UCL and Moorfields researcher. The international study observed that in eyes with sight loss caused by a particular genetic...
London, UK – Treatment of transthyretin-mediated amyloid cardiomyopathy (ATTR-CM) with acoramidis may significantly improve the 4-step primary hierarchical outcome containing components of mortality, morbidity, and function, with similar safety as placebo, according to an article published in The New England Journal of Medicine. “Acoramidis is a high-affinity TTR stabilizer that acts...
Bern, Switzerland – Researchers have developed a new method for triggering and imaging seizures in epilepsy patients, offering physicians the ability to collect real-time data to tailor epilepsy surgery. In contrast to previous practice, where physicians from neurology and nuclear medicine had to wait for hours to days in hopes...
OXFORD, UK – Digital clinical diagnostics and diabetes home testing provider Digostics revealed today the results from its ground-breaking gestational diabetes mellitus (GDM) remote screening collaboration with University Hospital Southampton NHS Foundation Trust (UHS), a partnership that saw expectant mothers in Hampshire become the first globally to access the gold...
Amsterdam, Netherlands – Water determines life: humans are three-quarters water. An international research team led by the University of Amsterdam (UvA) has now discovered how water also determines the structure of the material that holds us together: collagen. In a paper recently published in PNAS, the researchers elucidate the role...
Tucson, Arizona – A recent breakthrough study from the lab of Tanya Kalin, MD, PhD, professor of Child Health and Internal Medicine at the University of Arizona College of Medicine – Phoenix, has shown potential to improve therapeutic outcomes for patients suffering from lung cancers. “We have identified the novel protein FOXF1 that...
Barcelona, Spain – A study led by the University of Barcelona and the Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM) reveals how a new mechanism could improve the efficiency of currently available treatments for diabetes. The study, carried out on mice and cell cultures, may open...
Bath, England – Scientists have developed a new AI tool that maps the function of proteins in a cancerous tumour, enabling clinicians to decide how to target treatment in a more precise way. In cancers such as clear cell renal cell carcinoma (ccRCC), responses to existing treatments are different for...