Baltimore MD – A drug approved to treat pulmonary arterial hypertension may be effective at managing hypertension and end-organ damage in patients with sickle cell disease, according to a new study published in Lancet Haematology. An early phase randomized clinical trial involving 130 patients with sickle cell disease found that...
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MIAMI, FLORIDA – New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations has identified a next-generation BTK degrader that could help overcome treatment resistance in chronic lymphocytic leukemia (CLL) and related blood cancers. Their findings, published in the journal Science,...
Ann Arbor, MI – Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan Health researchers have studied the pathology of systemic sclerosis to understand better the disease and identify key pathways...
ANN ARBOR, Michigan — Researchers at the University of Michigan Health Rogel Cancer Center are exploiting a unique biological feature of glioblastoma to gain a better understanding of how this puzzling brain cancer develops and how to target new treatments against it. The team, led by senior author Pedro Lowenstein,...
Ann Arbor, Mich. – Bacteria in the mouth may play a role in survival from idiopathic pulmonary fibrosis (IPF), finds a new study led by researchers from the University of Michigan and the University of Virginia. The findings come from a larger analysis of the role of the lung microbiome...
ANN ARBOR, Michigan — Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer. They found the protein NSD2 alters the function of the androgen receptor, an important regulator of normal prostate development. When androgen...
Ann Arbor, Michigan – Researchers at the University of Michigan Health Rogel Cancer Center are one step closer to understanding how pediatric DIPG tumors work. Diffuse intrinsic pontine glioma, or DIPG, is the most aggressive pediatric brain tumor and incredibly difficult to treat since surgery isn’t feasible and recurrence is...
Ann Arbor, Michigan – People with higher levels of metals found in their blood and urine may be more likely to be diagnosed with — and die from — amyotrophic lateral sclerosis, or ALS, a University of Michigan-led study suggests. Researchers have known that ALS, a rare but fatal neurodegenerative...
Minneapolis, Minn. – Published in the Journal of Infectious Diseases, this research led by the University of Minnesota Medical School offers a new avenue of hope in the fight against chronic human immunodeficiency virus (HIV) infection. The researchers explored the use of Natural Killer (NK) cells aiming to restore their...
MINNEAPOLIS / ST. PAUL, Minn. — Researchers at the University of Minnesota, have developed a new visual diagnostic technique that can be used to advance early detection for neurodegenerative diseases like Parkinson’s disease and similar diseases that affect animals, including Chronic Wasting Disease in deer. The research is published in npj...