New York, NY – Like many rare diseases, fibrolamellar hepatocellular carcinoma (FLC) mounts a ferocious attack against an unlucky few—in this case, children, adolescents, and young adults. Because its symptoms can vary from person to person, it’s often missed or misdiagnosed until it has metastasized and becomes lethal. Moreover, drug...
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Cambridge, Mass. – Immunotherapy has revolutionized the treatment of many cancers, but brain tumors such as gliomas remain particularly difficult to treat, in part because they potently suppress immune responses. New findings from researchers at the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute (DFCI) could help...
Stanford, Calif. – CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven’t experienced improvement with chemotherapy treatments. But if this CAR-T treatment fails, or the cancer returns yet...
CLEVELAND, Ohio — A groundbreaking study by researchers at Case Western Reserve University suggests a class of medications used to treat type 2 diabetes may also reduce the risk of colorectal cancer (CRC). The findings, published in the journal JAMA Oncology, support the need for clinical trials to determine whether...
CLEVELAND, Ohio — Researchers at Case Western Reserve University and University Hospitals have identified an enzyme that blocks insulin produced in the body—a discovery that could provide a new target to treat diabetes. Their study, published Dec. 5 in the journal Cell, focuses on nitric oxide, a compound that dilates...
Hong Kong – The Centre for Chinese Herbal Medicine Drug Development of Hong Kong Baptist University (HKBU) has developed a new drug using effective components of a Chinese herbal medicine, Chaenomelis Fructus, for the treatment of the rare disease, myofibrillar myopathy. The drug has obtained the orphan drug designation from...
Sydney, Australia – Using artificial intelligence, Garvan Institute researchers have found potential cancer drivers hidden in so-called ‘junk’ regions of DNA, opening up possibilities for a new approach to diagnosis and treatment. Non-coding DNA – the 98% of our genome that doesn’t contain instructions for making proteins – could hold...
HUNTINGTON, W.Va. – A new clinical trial underway at Marshall University uses advanced medical device technology coupled with Computer-Aided Detection (CADe) systems, a form of artificial intelligence (AI), to reduce the risk of missed polyps, or lesions, during colonoscopy procedures. Gastroenterologists at the Marshall University Joan C. Edwards School of Medicine...
Madrid, Spain – Ewing sarcoma is a tumour of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare – 9 to 10 cases per million inhabitants per year – but it is very aggressive. 25% of patients do not respond...
Salt Lake City, Utah – A federally funded research team led by Sheri Holmen, PhD, investigator at Huntsman Cancer Institute and professor in the Department of Surgery at the University of Utah, is testing a new combination drug therapy that could both treat and prevent melanoma metastasis, or spreading from its original site, to...