SAN DIEGO, Calif. — Cardiff Oncology, Inc. (Nasdaq: CRDF), a clinical-stage biotechnology company leveraging PLK1 inhibition to develop novel therapies across a range of cancers, today announced that the first patient was dosed in its randomized first-line Phase 2 trial, CRDF-004, for patients with RAS-mutated metastatic colorectal cancer (mCRC). The...
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SHANGHAI, China — CARsgen Therapeutics Holdings Ltd, a company focused on innovative CAR T-cell therapies for the treatment of hematologic malignancies and solid tumors, announces that CT011, an autologous CAR T-cell product candidate against Glypican-3 (GPC3), has achieved Investigational New Drug (IND) clearance from the National Medical Products Administration (NMPA)...
Shijiazhuang, China – A teenage girl was diagnosed with concomitant Wilson disease (WD) and systemic lupus erythematosus (SLE), according to a case report published in Frontiers in Pediatrics. The 17-year-old patient was initially diagnosed with SLE following positive tests for lupus anticoagulant and antinuclear antibodies, along with pleural effusion, hypocomplementemia,...
The use of tyrosine kinase inhibitor (TKI) therapy may provide a degree of protection against COVID-19 in patients with chronic myeloid leukemia (CML). These findings are suggested by in a case report and literature review published in the European Journal of Case Reports in Internal Medicine. The case report involved a...
CLEVELAND, Ohio – Oral cancers and precancerous mouth lesions are considered especially difficult to diagnose early and accurately. For one, biopsies are expensive, invasive, stressful for the patient and can lead to complications. They’re also not feasible if repeated screenings of the same lesion are required. But a team of...
São Paulo, Brazil – Analysis of occurrence and co-occurrence patterns shows the highest-risk clusters of chikungunya and zika in Brazil spreading from the Northeast to the Center-West and coastal areas of São Paulo state and Rio de Janeiro state in the Southeast between 2018 and 2021, and increasing again in...
The largest analysis of its kind has found that Caucasians are much more likely than people in other racial/ethnic groups to develop a rare bone and soft tissue cancer called Ewing’s sarcoma. In addition, among Caucasians with this cancer, men are more likely to die than women. Published in the...
Houston, Texas – Researchers from The University of Texas MD Anderson Cancer Center reported promising results in a Phase I/II trial of 37 patients with relapsed or refractory B-cell malignancies who were treated with cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cell therapy targeting CD19. Published today in Nature...
Osaka, Japan – Much like ripples on the water can betray powerful currents below the surface, small changes in our bodies can sometimes be an indicator of a serious condition. Now, researchers from Japan say that cells in the blood may provide telltale signs of important immune dysfunction. In a...
CEBPA basic leucine zipper (CEBPA-bZip) mutations, whether monoallelic or biallelic, are associated with favorable outcomes from acute myeloid leukemia (AML), similar to those with CEBPA-double-mutated (CEBPA-dm), according to research published in Blood. CEBPA mutations are a common driver for AML and occur in 4% to 11% of patients. This analysis evaluated outcomes data across CEBPA mutation...