Boston, Mass. – Although primary open-angle glaucoma (POAG) is the leading cause of blindness in people over the age of 55, there remains no cure for the disease and its biological mechanisms are not well understood. Elevated intraocular pressure (IOP) is a major risk factor for the disease, but many...
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PORTLAND, Ore. – Researchers who work with tiny drug carriers known as lipid nanoparticles have developed a new type of material capable of reaching the lungs and the eyes, an important step toward genetic therapy for hereditary conditions like cystic fibrosis and inherited vision loss. Findings of the study led...
Osaka, Japan – Neuroendocrine tumors, including small cell lung cancer and neuroendocrine prostate cancer, are very aggressive with high chances of spreading. However, many individuals develop resistance to few available treatment options, leading to poor patient outcomes. Researchers are therefore aiming to develop new therapeutic methods that focus on the...
Lafayette, Indiana – For the first time, Purdue researchers prove that measuring mechanical motions in living cancer tissues is a viable and promising approach for predicting chemoresistance Chemotherapy can save lives, but often a cancer patient may be resistant to their prescribed chemotherapy, which costs the patient valuable time. Chemoresistance...
New York, NY – The macrophage is one of the body’s most important inhabitants. Meaning “big eater” in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris. Macrophages are especially important in the lungs, where they both fight bacterial infection and...
LA JOLLA, Calif. — Lung adenocarcinoma is the most common lung cancer and the cause of most cancer-related deaths in the United States. There are several ways lung adenocarcinoma can arise, one of which is a mutation in a protein called EGFR (epidermal growth factor receptor). Non-mutated EGFR helps...
La Jolla, Calif. – Antimicrobial resistance is a story of constantly moving parts and players. With every new or tweaked antibiotic or antimicrobial drug, the targeted pathogens begin the evolutionary dance of acquiring resistance, prompting researchers to constantly develop workarounds or entirely new classes of medicine. Understanding the underlying mechanisms...
Ottawa, ON – Surviving childhood cancer does not always mean a clean bill of health, as the treatments that eradicate those cancers can put adult survivors at risk of new cancers and other serious health problems. Despite the existence of surveillance guidelines that recommend screening for adult cancers and other...
The Sigma-1 receptor (S1R) is a transmembrane protein with important roles in stabilizing cellular functions in both normal physiology and disease. Especially in neurodegenerative diseases, S1R’s activity has been shown to provide neuronal protection by stabilizing the cell environment (based on the movement of calcium ions), improving mitochondrial function and...
Rockville, Maryland – New research conducted in mice offers insights into what’s going on at the molecular level that could cause people with diabetes to develop Alzheimer’s disease. The study adds to a growing body of research on the links between Type 2 diabetes and Alzheimer’s disease, which some scientists...