Nivolumab with or without ipilimumab as maintenance therapy after first-line chemotherapy failed to prolong survival among patients with extensive-disease small cell lung cancer (ED-SCLC), according to the results of the CheckMate 451 trial published in the Journal of Clinical Oncology. Although most patients with ED-SCLC respond to first-line chemotherapy, recurrence is...
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BOSTON, Mass. – NodThera, a leading clinical-stage biotech developing brain-penetrant NLRP3 inflammasome inhibitors to treat chronic inflammatory diseases, today announces positive data from its Phase Ib/IIa study in Parkinson’s disease patients, evaluating the effects of its oral, brain-penetrant NLRP3 inflammasome inhibitor NT-0796, on inflammatory and disease-specific biomarkers in the blood...
Deep vein thrombosis (DVT) after laparoscopic hepatectomy may be high, and no effective risk assessment methods exist. The authors of a study published in the Journal of Hepatocellular Carcinoma estimated incidence of DVT after surgery and created a DVT risk nomogram. The western hemisphere has well-established guidelines for thromboprophylaxis, but its application...
AMSTERDAM, Netherlands and LOUISVILLE, Ky. – NORGINE B.V. (Norgine) a leading European specialist pharmaceutical company and US WorldMeds (USWM), a Kentucky-based specialty pharmaceutical company, today announced an exclusive licensing agreement by which Norgine will register and commercialise difluoromethylornithine, DFMO (eflornithine) in Europe, Commonwealth of Independent States, Australia and New Zealand. DFMO is a repurposed molecule investigated for use...
EVANSTON, Ill. — Researchers led by Northwestern University and Washington University School of Medicine in St. Louis have developed a new, first-of-its-kind sticker that enables clinicians to monitor the health of patients’ organs and deep tissues with a simple ultrasound device. When attached to an organ, the soft, tiny sticker...
CHICAGO, Ill. — A new Northwestern Medicine study has found the immune system in the blood of Alzheimer’s patients is epigenetically altered. That means the patients’ behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that...
Evanston, Ill. – Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis (ALS). In a new study, researchers discovered a new way to enhance the body’s antioxidant response, which...
Evanston, Illinois — A team of Northwestern University scientists has developed the first wireless, implantable temperature sensor to detect inflammatory flareups in patients with Crohn’s disease. The approach offers long-term, real-time monitoring and could enable clinicians to act earlier to prevent or limit the permanent damage caused by inflammatory episodes....
CHICAGO, Illinois — A genetic change or variant in a gene called SCN2A is a known cause of infantile seizures, autism spectrum disorder and intellectual disability, as well as a wide range of other moderate-to-profound impairments in mobility, communication, eating and vision. The severity of these disorders can vary widely...
South Bend, Indiana – Certain types of light have proven to be an effective, minimally invasive treatment for cancers located on or near the skin when combined with a light-activated drug. But deep-seated cancers, surrounded by tissue, blood and bone, have been beyond the reach of light’s therapeutic effects. To...