Wiedemann Oldigs Oppermann syndrome


A rare syndrome characterized mainly by excessive hair growth, mental retardation and skeletal abnormalities.


* Hirsutism * Skeletal dysplasia * Mental retardation * Learning difficulties * Concentration difficulties


* PCOS and idiopathic –Estrogen-predominant oral contraceptives decrease plasma androgens –Depo-Provera may also be used –Spironolactone works by competing for androgen receptors –Cimetidine has a side effect of decreasing testosterone and increasing estrogen levels –GnRH agonist to facilitate better function of the hypothalamic-pituitary axis * Drug-induced: Eliminate causative medication if possible and hirsutism may resolve spontaneously * Hyperprolactinemia: Bromocriptine (prolactin antagonist)