Spastic paraplegia neuropathy poikiloderma


Spastic paraplegia - neuropathy - poikiloderma: A very rare syndrome characterized mainly by progressive stiffness and weakness of the legs, peripheral nerve degeneration and a skin disorder called poikiloderma. The eyelashes and eyebrows are usually gone by the age of three.


Loss of eyebrows Loss of eyelashes Amyotrophy Increased reflexes Increased muscle tone


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