Singleton-Merten Syndrome: A very rare disorder involving calcium abnormalities which affect the teeth, bones and blood vessels.
The list of signs and symptoms mentioned in various sources for Singleton-Merten Syndrome includes the 20 symptoms listed below: * Unerupted teeth * Missing teeth * Widened hand bones * Enlarged heart * Poor physical development * Psoriasis * Calcification of aorta * Calcification of aortic valve * Calcification of mitral valve * Osteoporosis * Malformed teeth * Premature primary teeth loss * Muscle weakness * Progressive muscle wasting * Growth retardation * Short stature * Delayed motor development * Thick red patches of scaly skin mainly on fingers * Hip malformation * Feet malformation Note that Singleton-Merten Syndrome symptoms usually refers to various symptoms known to a patient, but the phrase Singleton-Merten Syndrome signs may refer to those signs only noticable by a doctor.
The cause of primary osteoporosis is unknown; however, a mild but prolonged negative calcium balance, resulting from an inadequate dietary intake of calcium, may be an important contributing factor — as may declining gonadal or adrenal function, faulty protein metabolism due to estrogen deficiency, and sedentary lifestyle. Causes of secondary osteoporosis are many: prolonged therapy with steroids or heparin, total immobilization or disuse of a bone (as with hemiplegia, for example), alcoholism, malnutrition, malabsorption, scurvy, lactose intolerance, osteogenesis imperfecta, Sudeck’s atrophy (localized to hands and feet, with recurring attacks), and endocrine disorders (hypopituitarism, acromegaly, thyrotoxicosis, long-standing diabetes mellitus, hyperthyroidism). The incidence of osteoporosis is high, with an estimated 10 million U.S. residents suffering from osteoporosis and another 18 million suffering from low bone mass, or osteopenia. Incidence is higher in women than in men, with women older than age 50 accounting for 20% of cases. Another 30% of women have osteopenia, which can deteriorate into osteoporosis. Other Possible Causes of these Symptoms * Delayed motor development * Enlarged heart * Growth retardation * Malformed teeth * Missing teeth * Muscle weakness * Osteoporosis * Progressive muscle wasting * Short stature
The signs and symptom information on this page attempts to provide a list of some possible signs and symptoms of Singleton-Merten Syndrome. This medical information about signs and symptoms for Singleton-Merten Syndrome has been gathered from various sources, may not be fully accurate, and may not be the full list of Singleton-Merten Syndrome signs or Singleton-Merten Syndrome symptoms. Furthermore, signs and symptoms of Singleton-Merten Syndrome may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Singleton-Merten Syndrome symptoms.