Seminoma is one type of testicular cancer that is believed to originate from the germinal epithelium of the seminiferous tubules.
Peak incidence occurs in the 4th decade of life. Histology shows large cells, clear cytoplasm, distinct cell membranes, and septated architecture.
In recent years, these tumors have been shown to have dramatic sensitivity to both radiotherapy and cytotoxic chemotherapy. The management of childhood seminoma is similar to that of adult seminoma. Inguinal orchiectomy is required in almost all cases.