Post-orgasmic illness syndrome (POIS)


Post-orgasmic illness syndrome (POIS) is a condition characterized by debilitating symptoms following orgasm that last for a few hours up to several days. It appears to be principally a male orgasmic disorder and is believed to affect between 0.25-1% of the population. 


Symptoms are usually present within half an hour of orgasm. 

  • cognitive dysfunction
  • intense discomfort
  • irritability
  • anxiety
  • craving for relief
  • susceptibility to nervous system stresses (i.e. common cold)
  • depressed mood 
  • difficulty communicating
  • difficulty remembering words
  • difficulty reading and retaining information 
  • difficulty concentrating
  • difficulty socialising 
  • severe fatigue 
  • mild to severe headache 
  • flu-like/allergy-like symptoms (sneezing, itchy eyes, nasal irritation, muscle pain)
  • some experience intense warmth


might be due to low progesterone levels 

might be caused due to an allergy to males own semen that contributes to the symptoms of this illness 

One researcher suggests that the symptoms may be produced by an autoimmune reaction against any of various hormones or other substances secreted during and after sex.


POIS patients are beginning to be treated using hyposensitation techniques for semen allergies. 

Some patients respond to doses of norethisterone half and hour before, and in the minutes just after orgasm.  

Many affected individuals will typically avoid sexual activity, especially orgasm, or schedule sexual intercourse for times when they can rest and recover afterwards.