ZAP70 deficiency

ZAP70-related severe combined immunodeficiency (ZAP70-related SCID) is a cell-mediated immunodeficiency caused by abnormal T-cell receptor (TCR) signaling. Affected children usually present in the first year of life with recurrent bacterial, viral, and opportunistic infections, diarrhea, and failure to thrive. Severe lower respiratory infections and oral moniliasis are common. Affected children usually do not survive past their second year without hematopoietic stem cell transplantation (HSCT)

Zellweger syndrome

Zellweger syndrome (cerebrohepatorenal syndrome), is a rare congenital disorder characterized by the reduction or absence of functional peroxisomes in the cells of an individual. It is one of a family of disorders called leukodystrophies.

Zellweger syndrome is one of three peroxisome biogenesis disorders (PBD) which belong to the Zellweger spectrum of peroxisome biogenesis disorders (PBD-ZSD). The other two disorders are neonatal adrenoleukodystrophy (NALD), and infantile Refsum disease (IRD). Although all have a similar molecular basis for disease, Zellweger syndrome is the most severe of these three disorders. Zellweger syndrome is named after Hans Zellweger (1909–1990), a Swiss-American pediatrician, a professor of pediatrics and genetics at the University of Iowa who researched this disorder.

Zimmerman-Laband syndrome

Zimmerman-Laband syndrome (ZLS), also known as Laband's Syndrome, is an extremely rare genetic disorder characterized by gingival fibromatosis, coarse facial appearance, and absence or hypoplasia of nails or terminal phalanges of hands and feet.

Zlotogora syndrome

Zlotogora-Ogur syndrome is an ectodermal dysplasia syndrome characterized by hair, skin and teeth anomalies, facial dysmophism with cleft lip and palate, cutaneous syndactyly and, in some cases, intellectual disability.

Zollinger-Ellison syndrome

Zollinger-Ellison syndrome is a rare condition in which one or more tumors form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid. The excess acid then leads to peptic ulcers, as well as to diarrhea and other symptoms.

The primary tumor is usually located in the pancreas, duodenum or abdominal lymph nodes, but ectopic locations have also been described (e.g., heart, ovary, gallbladder, liver, kidney).

Zunich neuroectodermal syndrome

Zunich neuroectodermal syndrome: is a very rare ectodermal dysplasia syndrome characterized by a range of symptoms such as colobomas of the eye, heart defects, ichthyosiform dermatosis, mental retardation, conductive hearing loss and epilepsy.

Zuska’s Disease

Zuska's disease is rare but painful breast disorder that is not related to cancer but it is still a serious condition. Also known as "lactiferous fistula", or Zuska-Atkins disease, it is a rare and recurrent disorder characterized by draining abscesses around the nipple. Zuska's breast disease can also lead to nipple retraction.

Zuska's disease is not associated with pregnancy and lactation, it can occur in one or both breasts and can cause recurrent episodes of erysipela (streptococcus bacterial infection) and the presence of painful nodules under the areola.