Diseases

Spasmodic dysphonia

Spasmodic dysphonia (SD), a focal form of dystonia, is a neurological voice disorder that involves involuntary "spasms" of the vocal cords causing interruptions of speech and affecting the voice quality. SD can cause the voice to break up or to have a tight, strained, or strangled quality.

Spastic diplegia infantile type

Spastic diplegia, infantile type: A rare genetic disorder characterized by the early onset of lower leg spasticity and weakness and mental retardation.

Most children with diplegia have spaticity, and have difficulty with balance and coordination. Delayed muscle growth and spasticity cause their leg muscles to be short, and as a result the joints become stiff and the range of motion can decrease as a child grows. The feet and ankles present more problems than the knees, and the hips may become dislocated.

Spastic dysphonia

Spastic dysphonia: A rare speech disorder caused by stiffness of the muscles in the throat that control speech.

Spastic paraparesis

Tropical spastic paraparesis (TSP) is an infection of the spinal cord by Human T-lymphotropic virus resulting in paraparesis, weakness of the legs. As the name suggests, it is most common in tropical regions, including the Caribbean and Africa

Spastic paraplegia 20- autosomal recessive

Spastic paraplegia 20, autosomal recessive: A rare disorder characterized mainly by progressive stiffness, weakness and wasting of the lower leg muscles. The thumb muscle and speech is also affected

Spastic paraplegia 23

Spastic paraplegia 23: A rare disorder characterized mainly by progressive stiffness and weakness of the leg muscles, premature graying, characteristic facial appearance and a skin pigmentation anomaly. Pigmentation anomalies usually start from the age of 6 months and leg problems may be noticed around the middle of the first decade.

Spastic paraplegia 24

Spastic paraplegia 24: A rare genetic disorder characterized mainly by early onset of progressive weakness of the lower legs.

Spastic paraplegia 25- autosomal recessive

Spastic paraplegia 25, autosomal recessive: A rare genetic disorder characterized mainly by progressive weakness of the lower legs. The condition also involves herniation of spinal discs.

Spastic paraplegia 26- autosomal recessive

Spastic paraplegia 26, autosomal recessive: A rare genetic disorder characterized mainly by progressive weakness of the lower legs. The condition also involves herniation of spinal discs

Spastic paraplegia 29- autosomal dominant

Spastic paraplegia 29, autosomal dominant: A rare genetic disorder characterized mainly by progressive spasticity and weakness of the lower legs. The arms may also be affected in some cases.

Spastic paraplegia 3- autosomal dominant

Spastic paraplegia 3, autosomal dominant: A an early onset, very slow progressing form of spastic paraplegia which involves lower leg spasticity and weakness.

Spastic paraplegia 4- autosomal dominant

Spastic paraplegia 4, autosomal dominant: A rare syndrome characterized mainly by progressive stiffness and increased reflexes in the leg muscles. The severity of the condition is very variable as is the age of onset.

Spastic paraplegia 9- autosomal dominant

Spastic paraplegia 9, autosomal dominant: A rare disorder characterized by muscle wasting and weakness mainly in the legs, short stature, skeletal abnormalities and cataracts.

Spastic paraplegia neuropathy poikiloderma

Spastic paraplegia - neuropathy - poikiloderma: A very rare syndrome characterized mainly by progressive stiffness and weakness of the legs, peripheral nerve degeneration and a skin disorder called poikiloderma. The eyelashes and eyebrows are usually gone by the age of three.

Spastic paraplegia type 1- X-linked

Spastic paraplegia type 2 is part of a group of genetic disorders known as hereditary spastic paraplegias. These disorders are characterized by progressive muscle stiffness (spasticity) and the development of paralysis of the lower limbs (paraplegia). Hereditary spastic paraplegias are divided into two types: pure and complex. The pure types involve the lower limbs. The complex types involve the lower limbs and can also affect the upper limbs to a lesser degree; the structure or functioning of the brain; and the nerves connecting the brain and spinal cord to muscles and sensory cells that detect sensations such as touch, pain, heat, and sound (the peripheral nervous system). Spastic paraplegia type 2 can occur in either the pure or complex form

Spastic paraplegia type 5A- recessive

Spastic paraplegia type 5A, recessive: A rare disorder characterized mainly by progressive stiffness and weakness of lower leg muscles. Bladder and speech problems are also usually present.

Spastic paraplegia with Kallmann syndrome

Spastic paraplegia with Kallmann syndrome: A very rare genetic disorder characterized mainly by mild spasticity and weakness of the lower legs as well as lack of sex hormone production and an inability to smell.