Kyrle disease


Kyrle disease: A skin disorder often associated with diabetes mellitus or kidney failure.


The list of signs and symptoms mentioned in various sources for Kyrle disease includes the 7 symptoms listed below:

  • Papular eruptions
  • Hyperkeratotic cone-shaped papular plugs
  • Hyperkeratotic verrucous plaques
  • Diabetes mellitus
  • Hepatic insufficiency
  • Presence of albumin in the urine
  • Excess sugar in the urine

Note that Kyrle disease symptoms usually refers to various symptoms known to a patient, but the phrase Kyrle disease signs may refer to those signs only noticable by a doctor.


Other Possible Causes of these Symptoms

  • Diabetes mellitus


In cases of diffuse thickening of the skin, a thyroid profile with T 3 , T 4 , and TSH should be done. This should also identify hypothyroidism. A positive ANA test with a speckled pattern will help identify scleroderma, but a skin biopsy should also be done. An antisclerodermal antibody titer is also useful if available. Esophageal motility studies will be helpful in early diagnosis. A skin biopsy will help identify many of the other conditions mentioned above. Urine for porphyrins will help identify porphyria.