Hypertension caused by a reduced level of Kallikrein which is involved in controlling blood pressure through it's effect on kidney function. Reduced kallikrein secretion can be associated with hypertension.
* Reduced Kallikrein level * Hypertension
Gene therapy of hypertension requires long-term expression of a therapeutic gene to achieve stable reduction of blood pressure. Human tissue kallikrein (HK) cleaves kininogen to produce a potent vasoactive peptide kinin, which plays an important role in the regulation of the cardiovascular and renal functions