Glassy cell carcinoma of the cervix


Glassy cell carcinoma


Glassy cell carcinoma of the cervix, is a rare aggressive malignant tumour of the uterine cervix. The tumour gets its name from its microscopic appearance; its cytoplasm has a glass-like appearance.


The signs and symptoms are similar to other cervical cancers and may include post-coital bleeding and/or pain during intercourse (dyspareunia). Early lesions may be completely asymptomatic.


The diagnosis is based on tissue examination, e.g. biopsy.

Under the microscope, glassy cell carcinoma tumours are composed of cells with a glass-like cytoplasm, typically associated with an inflammatory infiltrate abundant in eosinophils and very mitotically active. PAS staining distinctively extenuates the plasma membrane.


The treatment is dependent on the stage. Advanced tumours are treated with surgery (radical hysterectomy and bilateral salpingo-opherectomy), radiation therapy and chemotherapy.