Gestational pemphigoid


Gestational Pemphigoid or Pemphigoid Gestationis (PG) is a rare autoimmune blistering skin disease that occurs during pregnancy, typically in the second or third trimester, and/or immediately following pregnancy. It was originally called herpes gestationis because of the blistering appearance, although it is not associated with the herpes virus.


* Severe burning skin sensation * Severe itchy skin * Multiform erythematous lesions * Vesicular lesions * Pustular lesions


The cause of PG is not known, although many researchers believe that the antibodies that protect the placenta become confused and begin to increase in number. These antibodies are directed at the skin and attack the protein that binds the outer layer of skin to the body. This action causes the skin to lift up, creating blisters.


PG often is confused with PUPPP (pruritic urticarial papules and plaques of pregnancy), especially if it occurs in a first pregnancy. PUPPP typically begins in stretch mark areas of the abdomen and usually ends within 2 weeks after delivery. PUPPP is not an autoimmune disease. Diagnosing PG is done by biopsy using direct immunofluorescence (DIF); appearance; and blood studies.


he most accepted way to treat PG is with the use of corticosteroids, i.e. prednisone; and/or topical steroids, i.e. clobetasol and betamethasone. Suppressing the immune system with corticosteroids helps by decreasing the number of antibodies that are attacking the skin. Treating PG can be difficult and can take several months. Some cases of PG persist for many years. There is no cure for PG. Women who have PG are considered in remission if they are no longer blistering. Remission can last indefinitely, or until a subsequent pregnancy. PG usually occurs in subsequent pregnancies; however, PG often seems more manageable because it is anticipated.