Crane-Heise syndrome


A very rare fatal disorder characterized by numerous abnormalities.


* Delayed fetal development * Large head * Widely spaced eyes * Depressed nasal bridge * Small face


Cleft lip or palate most commonly occurs as an isolated birth defect. Isolated cleft lip with or without cleft palate and cleft palate only are the result of a disruption in the normal development of the orofacial structures. This disruption in development is thought to be the result of a combination of genetic and environmental factors. Cleft lip or cleft palate may also occur as part of a chromosomal or Mendelian syndrome (cleft defects are associated with over 300 syndromes). Exposures to specific teratogens during fetal development may also produce these defects.