Chondrodysplasia- Grebe type


A rare genetic disorder characterized by dwarfism and various limb deformities.


* Dwarfism * Obesity * Shortened limbs * Very short legs * Short digits


Grebe syndrome is caused by a missense mutation in the gene encoding cartilage-derived morphogenetic protein-1. The protein encoded by the CDMP1 gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily