Chondrocalcinosis due to Apatite crystal deposition
Overview
A rare inherited disorder involving calcium pyrophosphate deposits in cartilage, joint fluid and tissues around joints.
Symptoms
* Morning stiffness * Pain * Limited range of spinal motion * Arthritis of the small joints in hands * Intervertebral disk calcifications
Causes
Although most cases of chondrocalcinosis are non-familial, there is considerable evidence that genetic factors are involved. Many multicase families with chondrocalcinosis have been reported [6–24]. Most familial cases appear to be inherited in an autosomal dominant manner, with early onset and varying severity even within families.
Prognosis
Disordered calcification of cartilage and ligaments occurs commonly amongst the elderly, yet the reasons for this are very poorly understood. Chondrocalcinosis affects 25% of the population aged over 85 yr and 3% of people aged between 65 and 69 yr show radiological evidence of the disease