Charcot-Marie-Tooth disease- Type 1C


CMT is an inherited neurological disease characterized by the gradual degeneration of nerves which starts in the hands and feet and results in progressive numbness, muscle weakness and loss of function. Type 1C is inherited as an autosomal dominant pattern and involves a defect in the LITAF/SIMPLE gene on chromosome 16.


* Slow running during childhood * High foot arches * Hammer toes * Foot weakness * Hand weakness * Balance problems * Foot drop * Wasted hand muscles * Wasted foot muscles * Hand pain * Foot pain * Wasted calf muscles * Weak calf muscles * Wasted arm muscles * Weak arm muscles * Sensory loss * Reduced nerve conduction speed * Reduced deep tendon reflexes


This medical information about signs and symptoms for Charcot-Marie-Tooth disease, Type 1C has been gathered from various sources, may not be fully accurate, and may not be the full list of Charcot-Marie-Tooth disease, Type 1C signs or Charcot-Marie-Tooth disease, Type 1C symptoms. Furthermore, signs and symptoms of Charcot-Marie-Tooth disease, Type 1C may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Charcot-Marie-Tooth disease, Type 1C symptoms.