Axial osteomalacia


Atypical osteomalacia involving the axial skeleton


Axial osteomalacia is a rare osteosclerotic disorder characterized by axial skeleton pain, coarsening of the trabecular bone pattern on radiographs of the axial but not appendicular skeleton. In this disorder an enzyme defect affects bone formation that primarily affects the ribs and iliac crest (hip bone).


  • Vague chronic axial pain
  • Back pain
  • Fatigue in extremities
  • Tenderness over lumbar spine
  • Limited spinal range motion
  • Impaired bone formation
  • Osteomalacia of rib
  • Osteomalacia of iliac crest


  • NIH