Acitretin embryopathy

Synonyms

Acitretin embryofetopathy
Fetal acitretin syndrome

Overview

Acitretin is an aromatic retinoid analog of vitamin A. Acitretin embryopathy has been known only in fetuses and the cause of this disease is a teratogenic disorder. this disorder is due to to acitretin or etretinate exposure during the first trimester of pregnancy, which leads to risk of fetal malformations.

Symptoms

  • 20% malformations of fetal including central nervous system
  • Craniofacial
  • Ear abnormalities
  • Thymic and cardiac defects
  • Limb irregularities

Resources

  • NIH