Acitretin is an aromatic retinoid analog of vitamin A. Acitretin embryopathy has been known only in fetuses and the cause of this disease is a teratogenic disorder. this disorder is due to to acitretin or etretinate exposure during the first trimester of pregnancy, which leads to risk of fetal malformations.
- 20% malformations of fetal including central nervous system
- Ear abnormalities
- Thymic and cardiac defects
- Limb irregularities