Acitretin embryopathy

Synonyms

2

Overview

Acitretin is an aromatic retinoid analog of vitamin A. Acitretin embryopathy has been known only in fetuses and the cause of this disease is a teratogenic disorder. this disorder is due to to acitretin or etretinate exposure during the first trimester of pregnancy, which leads to risk of fetal malformations.

Symptoms

  • 20% malformations of fetal including central nervous system
  • Craniofacial
  • Ear abnormalities
  • Thymic and cardiac defects
  • Limb irregularities

Resources

  • NIH