Diseases

Microphthalmia- syndromic 7

Microphthalmia, syndromic 7: A rare genetic disorder characterized by eye and skin abnormalities involving irregular red streaks of skin on the head and neck.

Microscopic polyangiitis

Microscopic polyangiitis (MPA) is an ill-defined autoimmune disease characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation. Because many different organ systems may be involved, a wide range of symptoms are possible in MPA. Purpura and livedo may be present.

Microsomia hemifacial radial defects

Microsomia - hemifacial - radial defects: A very rare syndrome characterized mainly by a wide range of defects involving the face, ear, mouth, vertebrae and radial bones.

Microspherophakia with hernia

Microspherophakia with hernia: A rare disorder characterized by myopia, detached retina, inguinal hernia and small, spherical, upward dislocated eye lens.

Microsporidiosis

Microsporidiosis: An infectious disease caused by a certain group of protozoa which form spores (microsporidia) e.g. Encephalitozoon, Enterocytozoon, Nosema, Pleistophora, Trachipleistophora, Vittaforma, Enterocytozoon bieneusi, Enterocytozoan )Septata) intestinalis). The protozoa invade and live inside the hosts cells. The release spores into the gastrointestinal tract where they are excreted and can infect other animals. The infection is often asymptomatic in healthy people but can cause serious symptoms affecting various parts of the body in immunocompromised people.

Microtia- meatal atresia and conductive deafness

We report on three sibs with right-sided microtia, meatal atresia, and conductive deafness. Two of the sibs also had right-sided palatoplegia. These sibs may have the autosomal-recessive form of microtia (No. 25180, McKusick [1983]), of which few familial cases are known to date. The malformation is due to a disturbance of the development of the first and second branchial arches. Review of the literature shows that microtia and meatal atresia with or without middle-ear involvement are developmental field defects which, either isolated or as a part of the facio-auriculovertebral spectrum, may occur (1) sporadically, (2) as component manifestation of syndromes, (3) as a multifactorial, or (4) as an apparent Mendelian trait.

Microtia-Anotia

Microtia is a condition in which the external portion of the ear (the auricle) is malformed. In the strictest definition, there is also narrowing or absence of the external auditory canal (external auditory meatus). This is different from a “small ear” in which the ear is normally shaped, but smaller than normal as in Down syndrome. Microtia varies in severity from barely discernable to an external ear with major structural changes. Anotia is the total absence of the auricle most often with narrowing or absence of the external auditory meatus. Anotia/microtia can occur unilaterally or bilaterally.

Microvillus inclusion disease

Microvillus Inclusion Disease: A rare, inherited, progressive intestinal disease where a defect in the intestinal wall results in severe diarrhea after birth.

Midline cleft of lower lip

Median cleft of lower lip and mandible is a rare anomaly. It has also been described as Cleft No. 30 of Tessier's classification. Couronne' reported the first account of this anomaly in 1819[1]. Since then very few cases have been reported in literature with different variations. We came across a patient with associated ectopic salivary gland on the dorsum of tongue. Case History A six-month-old, first born, male child presented to us with median cleft of lower lip [Figure:1]. The tongue was attached to the mandible and cleft margins of lower lip

Midline developmental field defects

Midline development field defects (medical condition): A medical term used to describe any condition involving two or more malformations of certain types. Malformations can include such things as oral clefts, neural tube defects, diaphragmatic hernias and omphaloceles. Midline development field defects: Another name for Schisis association (or close medical condition association). Schisis association: A medical term used to describe any condition involving two or more malformations of certain types. Malformations can include such things as oral clefts, neural tube defects, diaphragmatic hernias and omphaloceles.

Midline field defects

Midline field defects: Congenital problems that occur along the vertical axis of the body. Defects can involve the brain, spine, heart, genitals and midline of the head and face.

Midline lethal granuloma

Midline lethal granuloma: A rare condition involving progressive destruction of the midface region which includes the nose, sinuses, palate and even the eyes.

Midphalangeal hair

Midphalangeal hair: The presence of hair on the back of the middle finger bone.

Mikulicz syndrome

Mikulicz syndrome is a chronic condition characterized by the abnormal enlargement of glands in the head and neck, including those near the ears (parotids) and those around the eyes (lacrimal) and mouth (salivary). The tonsils and other glands in the soft tissue of the face and neck may also be involved. Although the disorder is almost always described as benign, it always occurs in association with another underlying disorder such as tuberculosis, leukemia, syphilis, Hodgkin’s disease, lymphosarcoma, Sjogren syndrome, or lupus (SLE). People who have Mikulicz syndrome are at heightened risk for developing lymphomas. Some people with Mikulicz syndrome may experience recurring fevers. The fever may be accompanied by dry eyes, diminished tear production (lacrimation), and inflammation of various parts of the eyes (uveitis). Lacrimal gland enlargement, parotid gland enlargement, dry mouth and dry eyes are the classic signs. 

Mikulicz’ Disease

Mikulicz's Disease: A rare condition involving enlargement of the salivary and tear-producing glands. If the enlargement as a result of another condition, it is called Mikulicz syndrome.

Miller Fisher syndrome

A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves.

Miller-Dieker syndrome

Miller-Dieker syndrome (MDS) is a rare genetic disorder. Its signs and symptoms include severe abnormalities in brain development as well as characteristic facial features. Additional birth defects may also be present. MDS was named for the two physicians, J. Miller and H. Dieker who independently described the condition in the 1960s. The hallmark of MDS is lissencephaly (smooth brain), a condition in which the outer layer of the brain, the cerebral cortex, is abnormally thick and lacks the normal convolutions (gyri). In some areas of the brain, gyri are fewer in number but wider than normal (pachygyri). Other areas lack gyri entirely (agyri). Normally, during the third and fourth months of pregnancy, the brain cells in the baby multiply and move to the surface of the brain to form the cortex. Lissencephaly is caused by a failure of this nerve cell migration. MDS is often called Miller-Dieker

Milner Khallouf Gibson syndrome

Milner-Khallouf-Gibson syndrome: A rare recessively inherited genetic disorder characterized by a variety of symptoms which are typical of a condition called Fanconi's anemia.

mineralizing angioplasty

My son , Andy Rakoczy , was diagnosed at Childens Hosp , Vancouver ,B.C with an expectation of almost immediate death , stroke or heart attack .Then they said he would surely die when it hit his brain stem and that happened at age 10 .They also did a biobsy of his brain and discovered the entire surface to be shrivelled and nothing they had seen before .He is now 25 ,severelly brain damaged but finding his way .He has learned and grown .Does his best in every situation .We have been told he is the only case in the world .He has far outlived expectation .

Minicore myopathy with external ophthalmoplegia

Minicore myopathy with external ophthalmoplegia: A rare congenital muscle disorder involving muscle weakness and wasting. The term minicore comes from the small core structures that occur in the muscle tissue. There are four subgroups of the disorder: classic form (rigid spine syndrome), progressive form with hand involvement, antenatal form with arthrogryposis multiplex congenital and the ophthalmoplegic form. The ophthalmoplegic form is distinguished by the presence of eye muscle weakness. The severity of symptoms is variable.

Minicore myopathy- antenatal onset- with arthrogryposis

Minicore myopathy, antenatal onset, with arthrogryposis: A rare congenital muscle disorder involving muscle weakness and wasting. The term minicore comes from the small core structures that occur in the muscle tissue. There are four subgroups of the disorder: classic form (rigid spine syndrome), progressive form with hand involvement, antenatal form with arthrogryposis multiplex congenital and the ophthalmoplegic form. The antenatal form with arthrogryposis is distinguished by the presence of contractures at birth due to reduced fetal movement as well as various physical anomalies. The severity of symptoms is variable.

Mirizzi syndrome

Mirizzi's syndrome is a rare cause of acquired jaundice. It is caused by chronic cholecystitis and large gallstones resulting in stenosis of the common bile duct. Occurs in approximately 0.1% of patients with gallstone disease[1] and 0.7-1.4% of patients undergoing cholecystectomy[2] It affects males and females equally, but tends to affect older people more often. There is no evidence of race having any bearing on the epidemiology.