Treatment Study for Actinic Cheilitis Comparing Imiquimod 5% and Photodynamic Therapy
Randomized Prospective Study Comparing 5% Imiquimod and Photodynamic Therapy for Actinic Cheilitis
Actinic cheilitis is a common precancerous lesion of the lip. The purpose of this study is to compare imiquimod 5% therapy and photodynamic therapy. The data will include effect data, histology (skin analysis), epidemiological data and follow-up data.
Randomized study comparing imiquimod 5% with photodynamic therapy for actinic cheilitis. Histological, efficacy, epidemiological and clinical data will be collected.
clinical and pathological complete cure rates.
clinical, safety, epidemiological and histopathological data
Study Arms / Comparison Groups
Description: Patients randomized to this arm will receive treatment with imiquimod 5%
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Primary Completion Date
Inclusion Criteria: - Clinical findings of actinic cheilitis. - Histological findings demonstrating epithelial changes equal to or greater than mild epithelial dysplasia in severity (mild - moderate - severe). - Age above 18. - Willingness to take post-treatment biopsy. Exclusion Criteria: - Disorders predisposing to photosensitivity (porphyria, SLE). - Pregnancy or nursing. - Known allergy to any excipients in the study creams. - prescribed topical retinoids, 5-fluorouracil, cryodestruction, surgical excision and curettage.
18 Years - N/A
Accepts Healthy Volunteers
Stein H Sundstrøm, PhD, ,
Norwegian University of Science and Technology
St. Olavs Hospital
Stein H Sundstrøm, PhD, Principal Investigator, St. Olavs Hospital