Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing’s Family of Tumors

Brief Title

Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors

Official Title

A Phase II Study Of Trabectedin (ET-743, Yondelis®) in Children With Recurrent Rhabdomyosarcoma, Ewing Sarcoma, or Nonrhabdomyosarcomatous Soft Tissue Sarcomas

Brief Summary

      This phase II trial is studying how well trabectedin works in treating young patients with
      recurrent or refractory soft tissue sarcoma or Ewing's family of tumors. Drugs used in
      chemotherapy such as trabectedin use different ways to stop tumor cells from dividing so they
      stop growing or die.

Detailed Description


      I. Determine the response rate in pediatric patients with recurrent or refractory soft tissue
      sarcomas or Ewing's sarcoma family of tumors treated with ecteinascidin 743 (trabectedin).

      II. Determine the toxicity of this drug in these patients. III. Determine the
      pharmacokinetics of this drug in these patients.


      Patients receive trabectedin IV over 3 hours on day 1. Treatment repeats every 21days for up
      to 26 courses in the absence of disease progression or unacceptable toxicity.

      After completion of study treatment, patients are followed up for up to 5 years.

Study Phase

Phase 2

Study Type


Primary Outcome

Response (Complete Response [CR] and Partial Response [PR])


Previously Treated Childhood Rhabdomyosarcoma



Study Arms / Comparison Groups

 Trabectedin 1.3 mg/m2 to assess feasibility in all patients
Description:  Patients receive trabectedin over 3 hours on day 1. Treatment repeats every 21 days for up to 26 courses in the absence of disease progression or unacceptable toxicity. A cohort of 6 patients will be enrolled at the 1.3 mg/m2 dose level.


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

January 2008

Completion Date

December 2013

Primary Completion Date

October 2010

Eligibility Criteria

        Inclusion Criteria:

          -  Patients must be greater than or equal to 12 months of age at the time of study entry
             and no more than 21 years of age when initially diagnosed with the malignancy to be
             treated on this protocol

          -  Histologically confirmed recurrent or refractory sarcoma tumors, including the

               -  Rhabdomyosarcoma

               -  Nonrhabdomyosarcomatous soft tissue sarcoma

               -  Ewing's sarcoma

          -  Measurable disease by imaging studies

               -  Lesions assessable only by radionuclide scans are not considered measurable

               -  If the only measurable lesion has been previously irradiated, then that lesion
                  must have shown evidence of an interim increase in size

          -  No significant amount of metastatic liver disease, defined as the following:

               -  Lesions occupying more than 25% of the liver by imaging and abnormal liver
                  function tests or abnormal synthetic liver function

          -  Performance status - Lansky 50-100% (10 years of age and under)

          -  Performance status - Karnofsky 50-100% (over 10 years of age)

          -  Absolute neutrophil count at least 1,000/mm^3

          -  Platelet count at least 100,000/mm^3 (transfusion independent)

          -  Hemoglobin at least 8.0 g/dL (transfusion allowed)

          -  No concurrent CYP3A4 inhibitors, including the following:

               -  Grapefruit juice

               -  Erythromycin

               -  Azithromycin

               -  Clarithromycin

               -  Rifampin and its analogs

               -  Fluconazole

               -  Ketoconazole

               -  Itraconazole

               -  Cimetidine

               -  Cannabinoids (marijuana or dronabinol)

               -  Leukotriene inhibitors used in asthma (e.g., zafirlukast, montelukast, or

          -  Bilirubin no greater than upper limit of normal (ULN)

          -  Total alkaline phosphatase no greater than ULN

          -  Hepatic fraction alkaline phosphatase and 5 nucleotidase no greater than ULN

          -  SGOT and SGPT ≤ 2.5 times ULN

          -  Albumin ≥ 2.5 g/dL

          -  Gamma-glutamyl transferase < 2.5 times ULN

          -  Maximum creatinine based on age as follows:

               -  0.8 mg/dL (5 years of age and under)

               -  1.0 mg/dL (6 to 10 years of age)

               -  1.2 mg/dL (11 to 15 years of age)

               -  1.5 mg/dL (over 15 years of age)

          -  Creatinine clearance or radioisotope glomerular filtration rate (GFR) at least 70

          -  No uncompensated congestive heart failure within the past 6 months

          -  Not pregnant or nursing

          -  Fertile patients must use effective contraception during and for 2 months after study

          -  No active uncontrolled infection

          -  Weight ≥ 15 kilograms

          -  More than 1 week since prior growth factors that support platelet or white blood cell
             number or function

          -  At least 7 days since prior biologic agents and recovered

          -  No prior allogeneic stem cell transplantation

          -  No other concurrent immunomodulating agents

          -  More than 3 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas)
             and recovered

          -  No more than 2 prior multi-agent chemotherapy regimens

          -  No other concurrent anticancer chemotherapy

          -  Concurrent steroids allowed

          -  At least 6 weeks since prior since prior extended radiotherapy and recovered

          -  No prior total body radiotherapy

          -  Concurrent radiotherapy to localized painful lesions allowed provided at least 1
             measurable lesion is not irradiated*

          -  At least 7 days since prior enzyme-inducing anticonvulsants (e.g., carbamazepine,
             phenobarbital, or phenytoin)

          -  No concurrent enzyme-inducing anticonvulsants

          -  No other concurrent investigational agents




12 Months - 50 Years

Accepts Healthy Volunteers



Sylvain Baruchel, MD, , 

Location Countries


Location Countries


Administrative Informations



Organization ID


Secondary IDs


Responsible Party


Study Sponsor

Children's Oncology Group


 National Cancer Institute (NCI)

Study Sponsor

Sylvain Baruchel, MD, Principal Investigator, Children's Oncology Group

Verification Date

August 2018