The Pathophysiology of Orthostatic Hypotension

Brief Title

The Pathophysiology of Orthostatic Hypotension

Official Title

The Pathophysiology of Orthostatic Hypotension

Brief Summary

      The purpose of this study is to determine the cause of low blood pressure in selective
      patients who have problems with their involuntary (autonomic) nervous system. These patients
      frequently have had symptoms throughout their life, and their disorder might have a genetic
      basis. The biochemical, physiological and pharmacological procedures in this study should
      help us define the problem and perhaps lead to more effective treatment.
    


Study Phase

Phase 1

Study Type

Interventional


Primary Outcome

hemodynamic changes with standing

Secondary Outcome

 blood and urine hormones

Condition

Autonomic Nervous System Diseases

Intervention

Standing or upright tilt

Study Arms / Comparison Groups

 A
Description:  Patients with Orthostatic Hypotension

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Procedure

Estimated Enrollment

10

Start Date

December 1996

Completion Date

December 2020

Primary Completion Date

December 2020

Eligibility Criteria

        Inclusion Criteria:

          -  severe orthostatic hypotension and other autonomic symptoms but do not meet criteria
             for standard diagnosis

          -  non-smokers

          -  drug-free

          -  able to give informed consent

          -  free of pulmonary, renal, hematopoietic, hepatic and cardiac disease

        Exclusion Criteria:

          -  medications affecting the autonomic nervous system

          -  any chronic illness

          -  anemia (Hct<30)

          -  women of childbearing age who are pregnant or nursing

          -  smokers
      

Gender

All

Ages

12 Years - 70 Years

Accepts Healthy Volunteers

No

Contacts

Emily M Garland, PhD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00748059

Organization ID

030752

Secondary IDs

HL056693

Responsible Party

Principal Investigator

Study Sponsor

Vanderbilt University Medical Center


Study Sponsor

Emily M Garland, PhD, Principal Investigator, Vanderbilt University


Verification Date

May 2021