Brief Title
The Pathophysiology of Orthostatic Hypotension
Official Title
The Pathophysiology of Orthostatic Hypotension
Brief Summary
The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. These patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. The biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.
Study Phase
Phase 1
Study Type
Interventional
Primary Outcome
hemodynamic changes with standing
Secondary Outcome
blood and urine hormones
Condition
Autonomic Nervous System Diseases
Intervention
Standing or upright tilt
Study Arms / Comparison Groups
A
Description: Patients with Orthostatic Hypotension
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Procedure
Estimated Enrollment
10
Start Date
December 1996
Completion Date
December 2020
Primary Completion Date
December 2020
Eligibility Criteria
Inclusion Criteria: - severe orthostatic hypotension and other autonomic symptoms but do not meet criteria for standard diagnosis - non-smokers - drug-free - able to give informed consent - free of pulmonary, renal, hematopoietic, hepatic and cardiac disease Exclusion Criteria: - medications affecting the autonomic nervous system - any chronic illness - anemia (Hct<30) - women of childbearing age who are pregnant or nursing - smokers
Gender
All
Ages
12 Years - 70 Years
Accepts Healthy Volunteers
No
Contacts
Emily M Garland, PhD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT00748059
Organization ID
030752
Secondary IDs
HL056693
Responsible Party
Principal Investigator
Study Sponsor
Vanderbilt University Medical Center
Study Sponsor
Emily M Garland, PhD, Principal Investigator, Vanderbilt University
Verification Date
May 2021