Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

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Brief Title

Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

Official Title

Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0

Brief Summary

      RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the
      laboratory may help doctors learn more about changes that occur in DNA and identify
      biomarkers related to cancer.

      PURPOSE: This research trial studies genes in samples from younger patients with
      adrenocortical tumor.
    

Detailed Description

      OBJECTIVES:

        -  To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation
           status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs)
           analysis in pediatric adrenocortical tumors and compare those results to those of the
           same patient's normal cells.

      OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep
      sequencing, micro RNA , methylation status, copy variation, and single-nucleotide
      polymorphisms. Results are then compared with patients' normal cells.
    


Study Type

Observational


Primary Outcome

Identification of genetic factors affecting adrenocortical tumors


Condition

Adrenocortical Carcinoma

Intervention

DNA methylation analysis


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Genetic

Estimated Enrollment

10

Start Date

February 2012


Primary Completion Date

May 2016

Eligibility Criteria

        DISEASE CHARACTERISTICS:

          -  Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in
             North America and Brazil

        PATIENT CHARACTERISTICS:

          -  Not specified

        PRIOR CONCURRENT THERAPY:

          -  Not specified
      

Gender

All

Ages

N/A - 21 Years

Accepts Healthy Volunteers

No

Contacts

Gerard Zambetti, PhD, , 



Administrative Informations


NCT ID

NCT01528956

Organization ID

ARAR12B1

Secondary IDs

COG-ARAR12B1

Responsible Party

Sponsor

Study Sponsor

Children's Oncology Group

Collaborators

 National Cancer Institute (NCI)

Study Sponsor

Gerard Zambetti, PhD, Principal Investigator, St. Jude Children's Research Hospital


Verification Date

May 2016