Brief Title
Studying Genes in Samples From Younger Patients With Adrenocortical Tumor
Official Title
Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0
Brief Summary
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research trial studies genes in samples from younger patients with
adrenocortical tumor.
Detailed Description
OBJECTIVES:
- To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation
status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs)
analysis in pediatric adrenocortical tumors and compare those results to those of the
same patient's normal cells.
OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep
sequencing, micro RNA , methylation status, copy variation, and single-nucleotide
polymorphisms. Results are then compared with patients' normal cells.
Study Type
Observational
Primary Outcome
Identification of genetic factors affecting adrenocortical tumors
Condition
Adrenocortical Carcinoma
Intervention
DNA methylation analysis
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Genetic
Estimated Enrollment
10
Start Date
February 2012
Primary Completion Date
May 2016
Eligibility Criteria
DISEASE CHARACTERISTICS:
- Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in
North America and Brazil
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
Gender
All
Ages
N/A - 21 Years
Accepts Healthy Volunteers
No
Contacts
Gerard Zambetti, PhD, ,
Administrative Informations
NCT ID
NCT01528956
Organization ID
ARAR12B1
Secondary IDs
COG-ARAR12B1
Responsible Party
Sponsor
Study Sponsor
Children's Oncology Group
Collaborators
National Cancer Institute (NCI)
Study Sponsor
Gerard Zambetti, PhD, Principal Investigator, St. Jude Children's Research Hospital
Verification Date
May 2016