Brief Title
Study Through Imaging of Visceral Lymphoid Organs in Patients With SCID Who Have Recieved Bone Marrow Allograft
Official Title
Study Through Imaging of Mediastinal and Abdominopelvic Secondary Lymphoid Organs (Lymph Nodes) in Patients With Severe Combined Immunodeficiencies (SCID) Who Have Recieved Bone Narrow Allograft
Brief Summary
To investigate the presence of seconday of lymphoid organs in patients who underwent allogenic hematopoietic stem cell transplantation 15 to 45 years ago. The goal aims to assess the development of seconday lymphoid organs given the fact that the absence of myeloablation these patients present a split chimerism between T lymphocytes and the other leucocytes. Thus, they may not be able to generate seconday lymphoid organs. Practically, whole body MRI is being used to visualise and quantify both mediastinal and intraabdominal lymph nodes. Delta will be compared with those obtained in healthy age-matched individuals. It is scheduled to include 15 patients and 15 controls.
Study Type
Observational
Primary Outcome
Size of mediastinal and intraabdominal lymph nodes
Condition
Severe Combined Immunodeficiency
Study Arms / Comparison Groups
Study group
Description: 15 adult patients who underwent allogenic hematopoietic stem cell transplantation (HSCT) for severe combined immunodeficieny 15 to 45 years ago
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
30
Start Date
February 1, 2020
Completion Date
February 1, 2021
Primary Completion Date
February 1, 2021
Eligibility Criteria
Inclusion Criteria: - Patients with SCID transplanted 15-45 years ago Exclusion Criteria: - None
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
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Administrative Informations
NCT ID
NCT04246840
Organization ID
AARIP-01
Responsible Party
Sponsor
Study Sponsor
Association Pour l'Aide a la Recherche en Immunologie Pediatrique
Study Sponsor
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Verification Date
January 2020