Brief Title
Study of the Environmental Factors Modulating Children Immune Response in Northern Senegal
Official Title
Study of the Environmental Factors Modulating Children Immune Response in Northern Senegal
Brief Summary
Longitudinal survey in Northern Senegal to investigate the environmental factors modulating
the immune response to childhood vaccines and to malaria.
A cohort of 410 children aged 1 to 10 from 5 villages of the Senegal River Valley(Podor
District) was followed-up for 18 months. During that period, 5 visits have been made to the
villages to assess the immunological and nutritional status of the children.
Detailed Description
Longitudinal survey in Northern Senegal to investigate the environmental factors modulating
the immune response to childhood vaccines and to malaria.
A cohort of 410 children aged 1 to 10 from 5 villages of the Senegal River Valley(Podor
District) was followed-up for 18 months. During that period, 5 visits have been made to the
villages to assess the immunological and nutritional status of the children (T1 (October
2008), T2 (January 2009), T3 (June 2009), T4 (October 2009) and T5 (January 2010)).
The project was approved by the National Ethics Committee of Senegal. Written individual
informed consent was obtained from each participant's parent or legal guardian at the
beginning of the survey, and at each visit child's and parent's approval was sought orally.
Capillary blood was collected from the finger tip of each child, using sterile single-use
material.
Body temperature was measured by means of auricular thermometer at all visits.
Anthropomorphic data were collected at visits T2, T3, T4 and T5.
A Hemocue photometer (HemoCue AB, Ängelholm, Sweden) was used to determine haemoglobin
concentration on a blood drop at visits T3, T4 and T5.
At each visit, a questionnaire was filled in for every child. Information was collected on
the date of birth family membership to asses if siblings or children living in the same house
were in the cohort.
Study Type
Observational
Condition
Whooping Cough
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
410
Start Date
October 2008
Completion Date
February 2010
Primary Completion Date
February 2010
Eligibility Criteria
Inclusion Criteria:
- Age: between 1 and 10 years
Exclusion Criteria:
- Fever (body temperature superior to 38.5 °C)
Gender
All
Ages
1 Year - 10 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Franck Remoué, PhD, ,
Location Countries
Senegal
Location Countries
Senegal
Administrative Informations
NCT ID
NCT01545115
Organization ID
EPLS08-JBS
Responsible Party
Sponsor
Study Sponsor
Biomedical Research Center EPLS
Collaborators
Institut Pasteur de Lille
Study Sponsor
Franck Remoué, PhD, Study Chair, Biomedical Research Center EPLS
Verification Date
March 2012