Role of Fibirnogen Like Protein 2 as Aprognostic Factor in High Grade Glioma

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Brief Title

Role of Fibirnogen Like Protein 2 as Aprognostic Factor in High Grade Glioma

Official Title

Role of Fibirnogen Like Protein 2 as Aprognostic Factor in High Grade Glioma

Brief Summary

      The study population was selected from high grade glioma pateints attending the Department of
      Clinical Oncology, Assiut University hospital during the period from December 2018 to
      September 2020, we analyzed human high grade gliomas paraffin block for FLG2 expression
    

Detailed Description

      Glioblastoma is the most common malignant primary brain tumor in adults, and despite
      aggressive treatment, it is incurable Patient prognosis differs considerably within the
      different World Health Organization (WHO) grades, poorest prognosis for patients with the
      grade IV tumour- the glioblastoma multiform (GBM).

      Fibrinogen-like protein 2 (FGL2),regulates both innate and adaptive immunity. FGL2 is a 439
      amino acid secreted protein that is similar to the β- and γ-chains of fibrinogen.

      Secreted FGL2 (sFGL2) is the key regulator in immunosuppression may play important role in
      malignant transformation of low to high by inhibiting the proliferation of T cell Study the
      role of fibrinogen-like protein2 on Immunosuppression and progression ,free survival and
      overall survival in high grade glioma
    


Study Type

Observational


Primary Outcome

Rple of FGL2in high grade glioma as aprognostic factor


Condition

Brain Tumor Adult

Intervention

FGL2 immunohisyochemistry


Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Genetic

Estimated Enrollment

1

Start Date

November 1, 2019

Completion Date

September 1, 2021

Primary Completion Date

September 1, 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Pateints>18 years old

          -  Pathologically proven high grade glioma

          -  Total or subtotal resection of the tumor

          -  Patients received concurrent radiation therapy with temozolomide followed by adjuvant
             temozolamide for 6 months

        Exclusion Criteria:

          -  Pregnancy

          -  Breast feeding

          -  Other comorbidity

          -  Previous malignancy or radiation therapy or chemotherapy
      

Gender

All

Ages

18 Years - 85 Years


Contacts

, 01222302375, [email protected]



Administrative Informations


NCT ID

NCT04113278

Organization ID

FGL2 in brain cancer


Responsible Party

Sponsor-Investigator

Study Sponsor

sohaila Essam


Study Sponsor

, , 


Verification Date

October 2019