Retrospective Chart Review of First-time Opsumit® (Macitentan) Users in the United States

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DNA Methylation Dynamics Underlying Arterial Remodeling in PAH Patients: CLEOPAHTRA Clinical Trial Effects of Oral Sildenafil on Mortality in Adults With PAH Inspiratory Muscle Training in Pulmonary Arterial Hypertension Dose Determination Safety and Activity Study of Inhaled NX1011 to Treat Pulmonary Arterial Hypertension MIF- Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension Safety, Tolerability, and PK Parameters of Sodium Nitrite Inhalation Solution in Healthy Subjects ARIES – Ambrisentan in Patients With Moderate to Severe Pulmonary Arterial Hypertension (PAH) BPS-314d-MR-PAH-303 (BEAT OLE) A Study to Investigate the Efficacy of PADN to Improved Functional Capacity and Hemodynamics in Patients With PAH A Study to Evaluate GSK1325760A – a Long-Term Extension Study Evaluation of Pulmonary Perfusion Heterogeneity and Compliance in Patients With Pulmonary Hypertension Using Positron Emission Tomography Imaging Trial of Iloprost Inhaled Solution as Add-On Therapy With Bosentan in Subjects With Pulmonary Arterial Hypertension (PAH) Phase III Randomized Study of UT-15 in Patients With Primary Pulmonary Hypertension Hemodynamic Evaluation of Dose-response and Safety of Dry Powder Inhalation of Treprostinil Efficacy and Safety of Oral Bosentan in Pulmonary Arterial Hypertension Class II Study of Cardiac MRI in the Follow up Assessment of Patients With PAH (EVITA) Beraprost-314d Added-on to Tyvaso® (BEAT) Effect of Pharmacologic Interaction Between ERAs and PDE-5 Inhibitors on Medication Serum Levels and Clinical Disease Status in Patients With PAH FDG Uptake and Lung Blood Flow in PAH Before and After Treatment With Ambrisentan Safety, Efficacy, and Treatment Satisfaction Switching From Flolan to Remodulin Using the Crono Five Ambulatory Pump in Patients With PAH A Study of Single Doses of MK -5475 on Pulmonary Vascular Resistance (MK-5475-002) Registry for Pulmonary Hypertension in China Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension Patients LenusPro Pump in PAH Treated With Treprostinil Hemodynamic Response After Six Months of Sildenafil Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy PAHTCH Pulmonary Arterial Hypertension Treatment With Carvedilol for Heart Failure (Carvedilol) Non-interventional Multi-center Study on Patients Under Routine Treatment of Pulmonary Arterial Hypertension (PAH) With Inhaled Iloprost Using I-Neb as a Device for Inhalation Endothelial Function in Patients With Pulmonary Arterial Hypertension A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With Pulmonary Arterial Hypertension (PAH) Repeatability and Sensitivity to Change of Non-invasive Endpoints in PAH Impact of Rehabilitation Program on PAH Patients Treated With Macitentan. Study to Assess Acute Vasodilation Response of Inhaled Nitric Oxide The Effect of Adding Exercise Training to Optimal Therapy in PAH Clinical Trial to Evaluate the Long-term Safety of Udenafil in Patient With PAH Effects of RT234 on Exercise Parameters Accessed by CPET in Subjects With PAH The Expression and Significance of MiRNA Treprostinil Combined With Tadalafil for Pulmonary Hypertension The “VISION” Trial: Ventavis Inhalation With Sildenafil to Improve and Optimize Pulmonary Arterial Hypertension Pharmacokinetics, Safety and Efficacy of BIA 5-1058 in PAH Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH) Olaparib for PAH: a Multicenter Clinical Trial Phase 2 Study of Ambrisentan for Liver Function Test Rescue in Pulmonary Arterial Hypertension Safety of Transition From Selexipag to Remodulin® Then Oral Treprostinil in Symptomatic Adult PAH Olaparib for PAH: a Pilot Study Rehabilitation for Patients With Pulmonary Arterial Hypertension Biomarkers in the Diagnosis and Assessment of Pulmonary Arterial Hypertension (PAH) Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE) ALlogeneic Cardiosphere-derived Stem Cells (CDCs) for Pulmonary Hypertension therApy Crossover Study From Macitentan or Bosentan Over to Ambrisentan Evaluation of Metformin Activity in Addition to Conventional Treatment of Grade II or III Pulmonary Arterial Hypertension (PAH) Study Of Right Ventricular Performance In PAH Patients Treated With Rapid Dose Treprostinil (Remodulin) Exercise Capacity and Quality of Life in Patients With PPH Receiving Short Term Oral L-Citrulline Malate BREATHE 5-OL: Tracleer (Bosentan) in Patients With Pulmonary Arterial Hypertension Related to Eisenmenger Physiology Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions Tamoxifen Therapy to Treat Pulmonary Arterial Hypertension Combined Use of Radiofrequency-ablation and Balloon-septostomy in the Creation of a Stable Inter-atrial Communication Therapy of Pulmonary Arterial Hypertension (PAH) – Treatment With Sildenafil in Eisenmenger Patients Clinical Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT Instrument Goal Oriented Strategy to Preserve Ejection Fraction Trial Safety, Pharmacokinetics and Efficacy Study of QCC374 in PAH Patients To Assess The Efficacy and Safety Of Oral Sildenafil in the Treatment of Pulmonary Arterial Hypertension. Remodulin® to Oral Treprostinil Transition Dose-response Study of the Safety and Efficacy of Beraprost Sodium Modified Release (BPS-MR) in Patients With Pulmonary Arterial Hypertension (PAH) Natural History Study of Biomarkers in Pulmonary Arterial Hypertension Combination Therapy in Pulmonary Arterial Hypertension Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH) Study of ACT-293987 (NS-304) in Pulmonary Arterial Hypertension (PAH) Open Label Study of Sildenafil in Patients With Pulmonary Arterial Hypertension Long Term Safety and Efficacy of Ralinepag in Pulmonary Arterial Hypertension Extension of BPS-MR-PAH-203 in Pulmonary Arterial Hypertension (PAH) Patients Study of Cicletanine for Pulmonary Arterial Hypertension (PAH) An Open-Label Extension of BPS-MR-PAH-201 in Pulmonary Arterial Hypertension (PAH) Patients Safety and Efficacy of APD811 in Pulmonary Arterial Hypertension Epoprostenol for Injection in Patients With Pulmonary Arterial Hypertension Efficacy of Ventavis Used in Real-life Setting. A Long-Term, Open-Label Study to Evaluate the Safety of Sitaxsentan Sodium Treatment in Patients With Pulmonary Arterial Hypertension FUTURE 3 Study Extension Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension Screening of Pulmonary Arterial Hypertension in BMPR2 Mutation Carriers Bronchodilator’s Effects on Exertional Dyspnoea in Pulmonary Arterial Hypertension Study of BSF 208075 Evaluating Exercise Capacity in Patients With Pulmonary Arterial Hypertension The PAH Platform for Deep Phenotyping in Korean Subjects Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension Beta-blockers in Pulmonary Arterial Hypertension Effects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH) A Transition Study From Flolan® to Remodulin® in Patients With Pulmonary Arterial Hypertension Phase III Clinical Worsening Study of UT-15C in Subjects With PAH Receiving Background Oral Monotherapy Safety Study of PLX-PAD Cells to Treat Pulmonary Arterial Hypertension (PAH) Effect of BMPR-2 Gene Mutations on Hemodynamic Response by Iloprost Inhalation in Pulmonary Arterial Hypertension Extension Study for Participants in LIQ861 Trials to Evaluate the Long-term Safety of Dry Powder Inhalation of Treprostinil Investigation of the Safety and Pharmacology of Dry Powder Inhalation of Treprostinil Pulmonary Arterial Hypertension Quality Enhancement Research Initiative Extension Program Safety Evaluation of Inhaled Treprostinil Administration Following Transition From Inhaled Ventavis in Pulmonary Arterial Hypertension (PAH) Subjects Acute Response of Iloprost Inhalation Using the Breelib Nebulizer in Pulmonary Arterial Hypertension Assessmet of Patients With PAH Right Ventricular Volume Imaging Control Study, 3D Echo, MR and RHC. [18F]FES PET/CT in PAH Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hypertension Related to Congenital Heart Disease Biomarkers in Pediatric Congenital Heart Disease and PAH The PAH Disability and Bothersomeness Questionnaire Efficacy, Safety, Tolerability and Pharmacokinetics (PK) of Nilotinib (AMN107) in Pulmonary Arterial Hypertension (PAH) Correlation OF Hemodynamics in Pulmonary Hypertension With Perfusion Lung Scans Ventavis® Registry Protocol Effect of Morphine on Dyspnea and 6-Minute Walk Distance in Pulmonary Arterial Hypertension A Randomized, Double-Blind, Placebo-Controlled Study of Sildenafil in Children With Pulmonary Arterial Hypertension. TRUST-2: Safety and Efficacy of Intravenous Remodulin® in Patients in India With Pulmonary Arterial Hypertension (PAH) Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension Open Label Access Study Of Sildenafil In Adult Patients With Pulmonary Arterial Hypertension Completing A1481244 Study 3D Imaging: Prognostic Role in Pulmonary Arterial Hypertension Home-based Exercise Training in Patients With Pulmonary Arterial Hypertension: Effect on Skeletal Muscular Function and Metabolism Reversible Secondary Myelofibrosis or Clonal Myeloproliferative Disorder Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging Observational Description of Compliance for the Daily Ventavis Use Via the Insight Program in Class III Pulmonary Arterial Hypertension Patients Study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in Patients With Pulmonary Arterial Hypertension Study to Compare Triple Therapy (Oral Treprostinil, Ambrisentan, and Tadalafil) With Dual Therapy (Ambrisentan, Tadalafil, and Placebo) in Subjects With Pulmonary Arterial Hypertension Safety, Tolerability, Pharmacokinetics and Efficacy of Two Different Rates of Subcutanous Remodulin® Dose Titration in Pulmonary Arterial Hypertension Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1) Safety And Efficacy Of Sildenafil In Children With Pulmonary Arterial Hypertension Safety and Efficacy of Inhaled Iloprost in Pediatric Patients With Pulmonary Arterial Hypertension A Multinational, Multicenter, Study to Assess the Efficacy and Safety of BPS-314d-MR in Subjects With Pulmonary Arterial Hypertension Currently Receiving Treatment With an Endothelin Receptor Antagonist and/or a Phosphodiesterase-5 Inhibitor Ventricular Reversed Remodeling After LTX in PAH Patients Pulmonary Artery Denervation for Treatment of Pulmonary Arterial Hypertension A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and Spain Open-Label Extension Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1) An Open Label Extension Study to Evaluate the Safety of Continued Therapy of Subcutanous Remodulin® in Pulmonary Arterial Hypertension A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension Inhaled Nitric Oxide/INOpulse DS for Pulmonary Arterial Hypertension (PAH) Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH Efficacy Study of Cardizem in Pulmonary Arterial Hypertension Modulating Effects of Lisinopril on Sildenafil Activity in Pulmonary Arterial Hypertension(PAH)( MELISSA) Acute Dosing of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-003) The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA) Post Marketing Observational Study in Patients With Pulmonary Arterial Hypertension ACT-293987 in Pulmonary Arterial Hypertension Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of MK-8892 in Participants With Pulmonary Arterial Hypertension (PAH) (MK-8892-005) A Study of Ranolazine Acute Administration and Short Term Administration in Pulmonary Arterial Hypertension A Long Term Study of Ambrisentan in Pulmonary Arterial Hypertension Subjects Having Completed AMB-320 (NCT00423748) or AMB-321 (NCT00423202) A Study of Ubenimex in Patients With Pulmonary Arterial Hypertension (WHO Group 1) A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH) An Open-Label, Long-Term Study of Oral Treprostinil in Subjects With Pulmonary Arterial Hypertension Estrogen Receptor Antagonist in Patients With Pulmonary Arterial Hypertension Fluoxetine in Pulmonary Arterial Hypertension (PAH) Trial Safety and Efficacy of Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Arterial Hypertension Who Were Previously Treated With Macitentan in Clinical Studies. A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension. A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension Clinical Study of Inhaled GB002 for Treatment of WHO Group I Pulmonary Arterial Hypertension BEET PAH: a Study to Assess the Effects of Beetroot Juice in Patients With Pulmonary Arterial Hypertension Efficacy and Safety Study of Udenafil in Patient With Pulmonary Arterial Hypertension(PAH) Long-term Study of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension Who Completed AIR001-CS05 Anastrozole in Patients With Pulmonary Arterial Hypertension Tezosentan in Patients With Pulmonary Arterial Hypertension Study to Assess Safety and Efficacy of Ambrisentan in Subjects With Pulmonary Arterial Hypertension. EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension A Phase 2 Study to Determine the Safety and Efficacy of AIR001 in Subjects With Pulmonary Arterial Hypertension (PAH) Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension. An Open-Label Extension Trial of UT-15C SR in Subjects With Pulmonary Arterial Hypertension Pilot Chart Review Study Of Sitaxentan Sodium (Thelin) In Patients With Pulmonary Arterial Hypertension (PAH) Pilot Study of the Safety and Efficacy of Carvedilol in Pulmonary Arterial Hypertension Feasibility of Slow-paced Respiration Therapy for Treatment of a Symptom Cluster in Pulmonary Arterial Hypertension Coenzyme Q-10 and Pulmonary Arterial Hypertension Sorafenib Study: Dosing in Patients With Pulmonary Arterial Hypertension (PAH) Study Providing Monotherapy (Sitaxsentan) And Combination Therapy (Sitaxsentan+Sildenafil) To Subjects With Pulmonary Arterial Hypertension (PAH) To Assess Long-Term Safety Addition of UT-15C SR to Pulmonary Arterial Hypertension Patients Currently Receiving Tyvaso® Oxygen Treatment and Pulmonary Arterial Hypertension A Therapeutic Open Label Study of Tocilizumab in the Treatment of Pulmonary Arterial Hypertension A Study of RVT-1201 in Patients With Pulmonary Arterial Hypertension (ELEVATE 1) Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension Pilot Study of the Safety and Efficacy of Anakinra in Pulmonary Arterial Hypertension The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study Tezosentan in Pulmonary Arterial Hypertension Oral CXA-10 in Pulmonary Arterial Hypertension Neuromuscular Electrical Stimulation in Pulmonary Arterial Hypertension Epoprostenol for Injection (EFI/ACT-385781A) – Pulmonary Arterial Hypertension Selonsertib in Adults With Pulmonary Arterial Hypertension Beta Blockers for Treatment of Pulmonary Arterial Hypertension in Children Beta-blockers in i-PAH Cardiac Function and Exercise Capacity in Pulmonary Arterial Hypertension (-)-Epicatechin and Pulmonary Arterial Hypertension DelIVery for Pulmonary Arterial Hypertension (PAH) Spironolactone for Pulmonary Arterial Hypertension Observation Study With Implantable Medication Pump for Intravenous Treprostinil Therapy in Patients With Pulmonary Arterial Hypertension Transforming Growth Factor Beta Signalling in the Development of Muscle Weakness in Pulmonary Arterial Hypertension Obstructive Sleep Apnea in Pulmonary Arterial Hypertension (OSA in PAH) Rt Ventricular Substrate Metabolism as a Predictor of Rt Heart Failure in Patients With Pulmonary Arterial Hypertension A Mobile Health Intervention in Pulmonary Arterial Hypertension Pharmacokinetic Study of Sub-q and IV Treprostinil in Kids With Pulmonary Arterial Hypertension (PAH) Apabetalone for Pulmonary Arterial Hypertension: a Pilot Study Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH) Effects of Two Dosing Regimens of Bosentan in Children With Pulmonary Arterial Hypertension Patient Reported Outcomes in Pulmonary Arterial Hypertension Extension to CQTI571A2102 to Evaluate Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH) Angiogenic Imaging in Pulmonary Arterial Hypertension Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension A Pharmacokinetics Study for Pediatric Participants With Pulmonary Arterial Hypertension Imatinib (QTI571) in Pulmonary Arterial Hypertension Study to Evaluate Efficacy and Safety of JTT-251 in Participants With Pulmonary Arterial Hypertension Epoprostenol for Injection in Pulmonary Arterial Hypertension – Extension of AC-066A401 Compassionate Use of Beraprost Sodium 314d Modified Release for Patients With Pulmonary Arterial Hypertension (PAH) Iloprost Power Disc-15 in Pulmonary Arterial Hypertension Study Performed at Various Medical Centers to Learn More About Survival and Expected Course of Pulmonary Arterial Hypertension, a Type of High Blood Pressure in the Lungs Related to the Narrowing of the Small Blood Vessels in the Lungs Epoprostenol for Injection in Pulmonary Arterial Hypertension Study of Intravenous Remodulin in Patients in India With Pulmonary Arterial Hypertension Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies Safety Study of the Switch From Oral Selexipag to Intravenous Selexipag in Subjects With Stable Pulmonary Arterial Hypertension Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument Aerobic Exercise Training in Pulmonary Arterial Hypertension Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension Bosentan in Children With Pulmonary Arterial Hypertension FK506 (Tacrolimus) in Pulmonary Arterial Hypertension Bosentan in Children With Pulmonary Arterial Hypertension Extension Study Evaluate The Clinical Effectiveness, Safety And Tolerability Of Sildenafil Used In Doses ≥20mg TID For The Treatment Of Pulmonary Arterial Hypertension Safety and Efficacy of Imatinib Mesylate in Patients With Pulmonary Arterial Hypertension Safety and Efficacy of Fluoxetine in Pulmonary Arterial Hypertension Central China Congenital Heart Disease Associated Pulmonary Arterial Hypertension Cohort Study Iron Deficiency In Pulmonary Hypertension Extension to QTI571A2301 to Evaluate the Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH) Genetic Research of Bone Morphogenetic Protein Receptor-II Gene in Taiwanese Patient With Primary Pulmonary Hypertension The Early Recognition of Pulmonary Arterial Hypertension Safety Study Extension of Iloprost Power 15 in Pulmonary Arterial Hypertension BMPR2 Mutations and Iron Metabolism in Pulmonary Arterial Hypertension Sildenafil to Tadalafil in Pulmonary Arterial Hypertension (SITAR) Responsiveness of Exercise Tests in Pulmonary Arterial Hypertension Combined Use of Angiography, Optical Coherence Tomography and Intravascular Ultrasound in Evaluation of Pulmonary Vascular Structure and Function in Patients With Pulmonary Arterial Hypertension Treated With Oral Bosentan Respiratory and Physical Therapy in Patients With Associated Pulmonary Arterial Hypertension (APAH) With Congenital Heart Defects Right Ventricular Metabolism in Pulmonary Arterial Hypertension Resynchronisation Therapy of Right Ventricle in Pulmonary Arterial Hypertension REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients Prevalence of the Hyperventilation Syndrome in Pulmonary Arterial Hypertension Iloprost Power 15 in Pulmonary Arterial Hypertension Selexipag (ACT-293987) in Pulmonary Arterial Hypertension Proof of Concept Study of IMMUNOadsorption Therapy in Patients With Idiopathic Pulmonary Arterial Hypertension Repeatability of OCT and IV-US in Pulmonary Arterial Hypertension Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension National Cohort Study of Idiopathic and Heritable Pulmonary Arterial Hypertension 6R-BH4 Pulmonary Arterial Hypertension Study Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Patients Safety and Feasibility of Autologous Endothelial Progenitor Cells Transplantation in Patients With Idiopathic Pulmonary Arterial Hypertension The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects

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