Response Inhibition Training for Children With Williams Syndrome

Brief Title

Response Inhibition Training for Children With Williams Syndrome

Official Title

Developing Treatments to Improve Psychosocial Functioning in Children With Williams Syndrome Part 1: Response Inhibition Training for Children With Williams Syndrome

Brief Summary

      The investigators will conduct a pilot study investigating the effectiveness of a
      computerized response inhibition training program at reducing the response inhibition
      difficulties often seen in children with Williams syndrome ages 10-17. The investigators
      hypothesize that after completing the training program, children with Williams syndrome will
      show improvement on computerized measures of response inhibition and on parent measures of
      impulsivity.
    

Detailed Description

      Behavioral characteristics of individuals with Williams syndrome include eagerness to
      approach and interact with others (including strangers), repeated questions especially about
      upcoming events, and difficulties with attention, impulsivity, and inhibition. There is very
      little systematic research about the kinds of interventions that are most useful for children
      with Williams syndrome to support optimal psychosocial functioning, and of the effectiveness
      of such interventions. We will conduct a pilot study of a potential intervention to address
      the response inhibition difficulties associated with Williams syndrome. The investigators
      will examine the utility of an online, web-based computerized cognitive retraining program
      aimed at addressing impulsivity and inhibition difficulties in 20 children, ages 10-17, with
      WS. The engaging training program has shown some utility in other populations, including
      children with tic disorders and trichotillomania. The investigators will examine the
      acceptability and feasibility of the treatment approach, as well as its impact on performance
      on experimental measures of impulsivity and on everyday psychosocial functioning as rated by
      parents; this study will consist of a small-scale pilot Randomized Clinical Trial with wait
      list. Through this novel work, we hope to develop and tune this approach for optimal outcomes
      and to demonstrate the promise of this intervention to address common challenges of people
      with Williams syndrome in the area of inhibition.
    


Study Type

Interventional


Primary Outcome

Cognitive Inhibition Tasks

Secondary Outcome

 Conners-3

Condition

Williams Syndrome

Intervention

Response Inhibition Training

Study Arms / Comparison Groups

 Response Inhibition Training
Description:  Treatment group will receive immediate treatment after pre-test.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Behavioral

Estimated Enrollment

25

Start Date

May 2014

Completion Date

May 2016

Primary Completion Date

May 2016

Eligibility Criteria

        Inclusion Criteria:

          -  Williams syndrome (diagnosed with genetic testing)

          -  Ages 10-17

          -  First language and main language spoken in the home is English

          -  Possess computer in the home that has internet access, and a second electronic device
             with access to Skype (e.g., smartphone, ipad, additional computer, ipod touch)

        Exclusion Criteria:

          -  First language and main language spoken in the home is NOT English (because study
             measures and instructions are all in English)

          -  No computer in the home with internet access (because the study is being conducted via
             the internet)

          -  Comorbid severe illnesses or major surgery within the past 6 months

          -  Four or more previous sessions of inhibition training
      

Gender

All

Ages

10 Years - 17 Years

Accepts Healthy Volunteers

No

Contacts

Bonita P Klein-Tasman, Ph.D., , 

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT02212314

Organization ID

14.351


Responsible Party

Principal Investigator

Study Sponsor

University of Wisconsin, Milwaukee


Study Sponsor

Bonita P Klein-Tasman, Ph.D., Principal Investigator, University of Wisconsin, Milwaukee


Verification Date

May 2017