Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

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Brief Title

Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

Official Title

Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

Brief Summary

      Investigate the prevalence of Toxoplasma gondii and Toxocara canis in Uveitis

        -  serum antibody to T. gondii and T. canis

        -  PCR with peripheral blood for T. gondii and T. canis

        -  PCR with aqueous humor for T. gondii and T. canis

        -  Clinical manifestation of patient with uveitis
    

Detailed Description

      Consecutive patients with uveitis are enrolled in Nune Eye Hospital.

      Serum ELISA

        -  IgM,IgG antibody to Toxoplasma gondii

        -  IgG antibody to Toxocara canis

      PCR

        -  PCR with serum and aqueous humor to Toxoplasma gondii

        -  PCR with serum and aqueous humor to Toxocara canis Clinical characteristics

        -  visual acuity

        -  intraocular pressure (IOP)

        -  location and degree of inflammation

        -  other fundus findings were recorded

      questionnaire

        -  environment, occupation

        -  pet ownership, exposure to animal

        -  history of eating raw liver of animal, raw beef or any other raw flesh of animal.
    


Study Type

Observational [Patient Registry]


Primary Outcome

Number of patients with positive result for serum antibody to Toxoplasma gondii and Toxocara canis

Secondary Outcome

 Number of patients with positive PCR with peripheral blood and aqueous humor to Toxoplasma gondii and Toxocara canis

Condition

Uveitis



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

98

Start Date

January 2011

Completion Date

February 2012

Primary Completion Date

February 2012

Eligibility Criteria

        Inclusion Criteria:

          -  patients with uveitis

        Exclusion Criteria:

          -  Patients with history of major ophthalmic surgery within 6 months

          -  antiviral, antifungal or antiparasitic therapy within 6 months
      

Gender

All

Ages

N/A - N/A

Accepts Healthy Volunteers

No

Contacts

Su Jin Lim, MD, , 



Administrative Informations


NCT ID

NCT01837056

Organization ID

Nuneuveitis


Responsible Party

Principal Investigator

Study Sponsor

National Institute of Health, Korea


Study Sponsor

Su Jin Lim, MD, Principal Investigator, Nune Eye Hospital


Verification Date

April 2013