Pharmacogenetic Study in Patients Received Iron Chelating Agent

Brief Title

Pharmacogenetic Study in Patients Received Iron Chelating Agent

Official Title

Pharmacogenetic Study in Patients Received Iron Chelating Agent

Brief Summary

      To investigate effect of genetic variations on the toxicities and find optimal target
      population, the investigators planned to analyze the genetic polymorphisms of
      UDP-glucuronosyltransferase.
    

Detailed Description

      Transfusion-associated iron overload induces systemic toxicity. Recently, deferasirox, a
      convenient long acting oral agent, has been introduced in clinical practice with promising
      efficacy. However, some patients experience drug-related toxicities and cannot tolerate it.
      To investigate effect of genetic variations on the toxicities and find optimal target
      population, we planned to analyze the genetic polymorphisms of UDP-glucuronosyltransferase 1A
      (UGT1A) subfamily, multi-drug resistance-associated protein 2 (MRP2) and breast cancer
      resistance protein (BCRP) among pediatric patients received deferasirox.
    


Study Type

Observational


Primary Outcome

Genetic polymorphism associated with side effects of deferasirox


Condition

Hemosiderosis



Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

100

Start Date

December 2007

Completion Date

June 2013

Primary Completion Date

June 2013

Eligibility Criteria

        Inclusion Criteria:

          1. Patients who received deferasirox because of transfusion associated iron overload
             (Transfusion associated iron overload was defined as ferritin ≥ 1,000 ng/mL in
             patients who needed over 8 units of RBC transfusions per a year).

          2. Patients with written informed consents

        Exclusion Criteria:

        Patients or parents refusal
      

Gender

All

Ages

N/A - 21 Years

Accepts Healthy Volunteers

No

Contacts

, , 

Location Countries

Korea, Republic of

Location Countries

Korea, Republic of

Administrative Informations


NCT ID

NCT01623895

Organization ID

SNUCH-R-0701


Responsible Party

Principal Investigator

Study Sponsor

Seoul National University Hospital


Study Sponsor

, , 


Verification Date

December 2013