PAI-1 Expression in Non-scarring Hair Loss

Brief Title

PAI-1 Expression in Non-scarring Hair Loss

Official Title

Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.

Brief Summary

      This study will investigate whether subjects who suffer from hair loss have increased levels
      of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be
      determined in subjects without hair loss and in subjects with non-scarring hair loss,
      including androgenetic alopecia, telogen effluvium and alopecia areata.
    

Detailed Description

      This study will compare the levels of PAI-1 expression in subjects with different forms of
      non-scarring hair loss and in these subjects vs normal age-matched controls. Hair loss
      subjects will have their Northwestern Memorial Hospital and Northwestern Medical Faculty
      Foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. All
      subjects will have a 4 mm punch biopsy on the scalp. Tissue PAI-1 levels from scalp skin
      biopsies will be determined by immunohistochemical staining. Samples will be kept for
      approximately 15 years, after which time unused samples will be destroyed.
    

Study Type

Observational

Primary Outcome

PAI-1 expression level in scalp skin biopsy samples

Condition

Androgenetic Alopecia

Study Arms / Comparison Groups

 Non-scarring hair loss

Description:  Patients seen at Northwestern Memorial Hospital or Northwestern Medical Faculty Foundation physician offices that have undergone evaluation for hair loss and have a diagnosis of androgenetic alopecia, telogen effluvium or alopecia areata.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Estimated Enrollment

55

Start Date

July 2015

Completion Date

June 2020

Primary Completion Date

June 2020

Eligibility Criteria

        Inclusion Criteria:

          -  Age-matched control subjects who do not have a history of hair loss

          -  A clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium,
             alopecia areata or normal scalp skin

          -  All subjects must have given signed, informed consent prior to registration in study

        Exclusion Criteria:

          -  History of previous hair transplantation

          -  Current and past use of medications topically on the scalp

          -  Clinical or pathologic diagnosis of a scarring alopecia

          -  History of inflammatory conditions of the scalp such as psoriasis
      

Gender

All

Ages

18 Years - 60 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Maria Colavincenzo, MD, , 

Location Countries

United States

Location Countries

United States

NCT ID

NCT02548689

Organization ID

STU00103009

Responsible Party

Principal Investigator

Study Sponsor

Northwestern University

Study Sponsor

Maria Colavincenzo, MD, Principal Investigator, Northwestern University Feinberg School of Medicine

Verification Date

November 2019