Brief Title
PAI-1 Expression in Non-scarring Hair Loss
Official Title
Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.
Brief Summary
This study will investigate whether subjects who suffer from hair loss have increased levels of PAI-1 compared to age-matched control subjects. The level of PAI-1 expression will be determined in subjects without hair loss and in subjects with non-scarring hair loss, including androgenetic alopecia, telogen effluvium and alopecia areata.
Detailed Description
This study will compare the levels of PAI-1 expression in subjects with different forms of non-scarring hair loss and in these subjects vs normal age-matched controls. Hair loss subjects will have their Northwestern Memorial Hospital and Northwestern Medical Faculty Foundation medical records reviewed to ensure they meet inclusion and exclusion criteria. All subjects will have a 4 mm punch biopsy on the scalp. Tissue PAI-1 levels from scalp skin biopsies will be determined by immunohistochemical staining. Samples will be kept for approximately 15 years, after which time unused samples will be destroyed.
Study Type
Observational
Primary Outcome
PAI-1 expression level in scalp skin biopsy samples
Condition
Androgenetic Alopecia
Study Arms / Comparison Groups
Non-scarring hair loss
Description: Patients seen at Northwestern Memorial Hospital or Northwestern Medical Faculty Foundation physician offices that have undergone evaluation for hair loss and have a diagnosis of androgenetic alopecia, telogen effluvium or alopecia areata.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
55
Start Date
July 2015
Completion Date
June 2020
Primary Completion Date
June 2020
Eligibility Criteria
Inclusion Criteria: - Age-matched control subjects who do not have a history of hair loss - A clinical and pathologic diagnosis of androgenetic alopecia, telogen effluvium, alopecia areata or normal scalp skin - All subjects must have given signed, informed consent prior to registration in study Exclusion Criteria: - History of previous hair transplantation - Current and past use of medications topically on the scalp - Clinical or pathologic diagnosis of a scarring alopecia - History of inflammatory conditions of the scalp such as psoriasis
Gender
All
Ages
18 Years - 60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Maria Colavincenzo, MD, ,
Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT02548689
Organization ID
STU00103009
Responsible Party
Principal Investigator
Study Sponsor
Northwestern University
Study Sponsor
Maria Colavincenzo, MD, Principal Investigator, Northwestern University Feinberg School of Medicine
Verification Date
November 2019