Brief Title
Neuromuscular Ultrasound in ALS
Official Title
Ultrasonography in Amyotrophic Lateral Sclerosis as a Predictor of Disease Progression and Tool in Diagnosis: a Pilot Study
Brief Summary
Amyotrophic Lateral Sclerosis (ALS) is a progressive fatal neurodegenerative disease affecting motor neurons. Early diagnosis is essential for the success of clinical trials and objective biomarkers are needed for monitoring disease progression. Nerve and muscle ultrasound may provide this information. This study will collect pilot data to evaluate the value of muscle and nerve ultrasound to identify and monitor disease progression in ALS.
Study Type
Observational
Primary Outcome
Abnormalities at onset: Ultrasound vs. Electromyography
Secondary Outcome
Ultrasound Predicting Outcome at 1 year
Condition
ALS
Intervention
Ultrasound of nerve and muscle
Study Arms / Comparison Groups
Control Group
Description: No intervention to be performed.
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
40
Start Date
February 2013
Completion Date
March 2015
Primary Completion Date
March 2015
Eligibility Criteria
Inclusion Criteria: - Subjects referred to the electromyography laboratory for ALS. Exclusion Criteria: - Patients with known comorbid myopathy or neuropathy will be excluded from the study. - Patients unable to provide their own consent will be excluded.
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
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Location Countries
United States
Location Countries
United States
Administrative Informations
NCT ID
NCT01785550
Organization ID
Pro00042025
Responsible Party
Sponsor
Study Sponsor
Duke University
Study Sponsor
, ,
Verification Date
March 2015