MRI in Diagnosing and Monitoring CIDP

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Brief Title

MRI in Diagnosing and Monitoring CIDP

Official Title

Magnetic Resonance Imaging and Ultrasound Imaging of Peripheral Nerves in Patients Treated With Immunoglobulin in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.

Brief Summary

      We want to study whether MRI can be useful in diagnosing and monitoring patients with CIDP in
      maintenance treatment with immunoglobulin
    

Detailed Description

      Chronic inflammatory neuropathies such as chronic inflammatory demyelinating
      polyradiculoneuropathy (CIDP) can be successfully treated with immunoglobulin either
      intravenously (IVIG) or subcutaneously (SCIG).

      CIDP is diagnosed by electrophysiology which is time-consuming and unpleasant for the
      patient.

      New techniques suggest that Magnetic Resonance Imaging (MRI) and ultrasound imaging can be
      used to detect injuries in the peripheral nerves

      We want to study if MRI and ultrasound is able to detect damages in peripheral nerves, nerve
      roots and plexus in patients with CIDP.

      Moreover, we want to compare these findings to healthy matched controls and to see if
      treatment with immunoglobulin changes findings in MRI
    


Study Type

Observational


Primary Outcome

DTI changes in nerves and muscles

Secondary Outcome

 Changes in MRI findings between treated and untreated CIDP patients

Condition

Chronic Inflammatory Demyelinating Polyradiculoneuropathy


Study Arms / Comparison Groups

 CIDP - treated
Description:  Patients diagnosed with CIDP and fulfilling the criteria by EFNS and PNS and in maintenance treatment with subcutaneous immunoglobulin

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

39

Start Date

May 2014

Completion Date

May 2016

Primary Completion Date

May 2016

Eligibility Criteria

        Inclusion Criteria:

        CIDP patients

          -  Age > 18 and < 80 years

          -  Diagnosed with definite and probable CIDP and fulfilling the European Federation of
             Neurological Sciences/Peripheral Nerve Society (EFNS/PNS) criteria

        Healthy controls

          -  Age > 18 and < 80 years

          -  No neurological disorders

        Exclusion Criteria:

          -  Age < 18 or > 80 years

          -  Contraindications to MRI

          -  Pregnancy

          -  Other cause of neuropathy (incl. pressure neuropathy)

          -  Diabetes mellitus
      

Gender

All

Ages

18 Years - 80 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

Henning Andersen, Prof, DMSc, , 

Location Countries

Denmark

Location Countries

Denmark

Administrative Informations


NCT ID

NCT02017769

Organization ID

2012-100


Responsible Party

Sponsor

Study Sponsor

University of Aarhus


Study Sponsor

Henning Andersen, Prof, DMSc, Principal Investigator, 


Verification Date

August 2016