Brief Title
MRI in Diagnosing and Monitoring CIDP
Official Title
Magnetic Resonance Imaging and Ultrasound Imaging of Peripheral Nerves in Patients Treated With Immunoglobulin in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.
Brief Summary
We want to study whether MRI can be useful in diagnosing and monitoring patients with CIDP in maintenance treatment with immunoglobulin
Detailed Description
Chronic inflammatory neuropathies such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) can be successfully treated with immunoglobulin either intravenously (IVIG) or subcutaneously (SCIG). CIDP is diagnosed by electrophysiology which is time-consuming and unpleasant for the patient. New techniques suggest that Magnetic Resonance Imaging (MRI) and ultrasound imaging can be used to detect injuries in the peripheral nerves We want to study if MRI and ultrasound is able to detect damages in peripheral nerves, nerve roots and plexus in patients with CIDP. Moreover, we want to compare these findings to healthy matched controls and to see if treatment with immunoglobulin changes findings in MRI
Study Type
Observational
Primary Outcome
DTI changes in nerves and muscles
Secondary Outcome
Changes in MRI findings between treated and untreated CIDP patients
Condition
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Study Arms / Comparison Groups
CIDP - treated
Description: Patients diagnosed with CIDP and fulfilling the criteria by EFNS and PNS and in maintenance treatment with subcutaneous immunoglobulin
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Estimated Enrollment
39
Start Date
May 2014
Completion Date
May 2016
Primary Completion Date
May 2016
Eligibility Criteria
Inclusion Criteria: CIDP patients - Age > 18 and < 80 years - Diagnosed with definite and probable CIDP and fulfilling the European Federation of Neurological Sciences/Peripheral Nerve Society (EFNS/PNS) criteria Healthy controls - Age > 18 and < 80 years - No neurological disorders Exclusion Criteria: - Age < 18 or > 80 years - Contraindications to MRI - Pregnancy - Other cause of neuropathy (incl. pressure neuropathy) - Diabetes mellitus
Gender
All
Ages
18 Years - 80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Contacts
Henning Andersen, Prof, DMSc, ,
Location Countries
Denmark
Location Countries
Denmark
Administrative Informations
NCT ID
NCT02017769
Organization ID
2012-100
Responsible Party
Sponsor
Study Sponsor
University of Aarhus
Study Sponsor
Henning Andersen, Prof, DMSc, Principal Investigator,
Verification Date
August 2016