Laryngeal Adaptation for Speech and Swallowing

Brief Title

Laryngeal Adaptation for Speech and Swallowing

Official Title

Laryngeal Adaptation for Speech and Swallowing

Brief Summary

      This study will test laryngeal adaptation in speech and swallowing function in healthy
      adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6.
      The findings from this proposal will be the first step toward implementing rehabilitation
      techniques that help patients to prevent speech and swallowing errors before they occur.
    

Study Type

Interventional

Primary Outcome

Laryngeal Adaptation in Speech

Condition

Stroke

Intervention

Intermittent Perturbation to Continuous Perturbation

Study Arms / Comparison Groups

 Stroke without Dysarthria

Description:  Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Status

Device

Estimated Enrollment

0

Start Date

August 24, 2018

Completion Date

August 30, 2019

Primary Completion Date

August 30, 2019

Eligibility Criteria

        Patient Inclusion Criteria:

        All stroke and ataxia

        Ataxia

          -  DNA diagnosis of SCA6 and phenotype consistent with the DNA diagnosis

          -  No recessive, X-linked or mitochondrial

        Stroke

          -  Bilateral or unilateral middle cerebral artery (MCA) stroke

          -  No structural abnormalities (i.e. nodules)

          -  Dysphagia involving laryngeal dysfunction

        Stroke and ataxia with speech and swallowing disorders

          -  no structural abnormalities

          -  dysphagia involving laryngeal dysfunction

        Patient Exclusion Criteria:

          -  Montreal Cognitive Assess. <24

          -  Moderate to severe hearing loss

          -  Barium allergy

          -  Other confounding speech disorder (i.e. stuttering)

          -  Chemo-radiation, surgical head and neck treatment

          -  Smoking Hx in the past 5 yrs or >5 years at any one time

          -  Twenty one years of age or older

          -  Breathing disorders or diseases
      

Gender

All

Ages

21 Years - 100 Years

Accepts Healthy Volunteers

Accepts Healthy Volunteers

Contacts

, , 

NCT ID

NCT03770377

Organization ID

IRB201702917 -A

Secondary IDs

R01DC016275-01A1

Responsible Party

Sponsor

Study Sponsor

University of Florida

Collaborators

 National Institute on Deafness and Other Communication Disorders (NIDCD)

Study Sponsor

, , 

Verification Date

June 2021