Investigation of the Human Immune Response in Normal Subjects and Patients With Disorders of the Immune System and Cancer

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Brief Title

Investigation of the Human Immune Response in Normal Subjects and Patients With Disorders of the Immune System and Cancer

Official Title

Collection of Blood, Bone Marrow and Tissue Samples for the Investigation of the Human Immune Response, Lymphoma Biology and HTLV-1 Infection

Brief Summary

      This protocol is being submitted to consolidate, update, and expand two previously approved
      protocols (77-C-0066 and 82-C-0044) into a single protocol. The purpose of this study is to
      examine the factors involved in the regulation of the immune system of healthy individuals
      and to define the abnormalities in this regulation that underlies the immunological disorders
      of patients with a variety of immunodeficiency and malignant disorders. The studies will
      include the ex vivo phenotypic and functional analysis of the network of cells involved in
      humoral and cellular immune responses, and in vivo testing for the capacity to make
      delayed-type hypersensitivity and humoral responses following immunization with a variety of
      antigens. Individuals to be studied will include patients with a variety of malignancies and
      patients with primary and secondary immunodeficiency disorders. Selected family members or
      family members known to be genetic carriers of certain immunodeficiency diseases as well as
      normal, unrelated individuals will also be studied. A small number of procedures will be used
      including analysis of blood obtained by phlebotomy, apheresis, skin testing and recall
      antigens and immunization to assess humoral immunity.
    

Detailed Description

      Background:

        -  The evaluation of the cells of the immune system and HTLV-1 infection have been a
           central focus of the Metabolism Branch for the past 30 years.

        -  Blood obtained by apheresis or blood drawing, skin biopsies and other tissues will be
           evaluated for abnormalities related to immunity, HTLV-1 infection and the immune system.

        -  Advances in the characterization of acquired genetic changes in tumor samples has

      led to insights for the development of targeted therapy of malignancy

      Objectives:

        -  To characterize the molecular biology and immunological features as well as the clinical
           course of individuals with suspected or known disorders of the immune system or cancer

        -  To define the nature of the immunological, genetic and epigenetic abnormalities in the
           cells of participants with immunodeficiency diseases associated with infections and/or a
           high incidence of malignancy and in participants with cancer.

        -  To obtain whole blood, plasma and leukocytes, as well as skin, lymph node and bone
           marrow biopsies on participants with immunodeficiency or cancer to investigate the
           immune system.

      Eligibility:

        -  Subjects with cancer.

        -  Subjects with immunodeficiency.

        -  Subjects with HTLV-1 infection.

      Design:

      -This is a natural history study that permits tissue acquisition for analysis of the immune
      system and HTLV-1 infection.
    


Study Type

Observational


Primary Outcome

Create Biobank


Condition

T-cell Lymphoma


Study Arms / Comparison Groups

 1
Description:  Suspected or known disorder of the immune system or cancer; or, known or potential carrier of autoimmune disorder or immunodeficiency disease.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information



Estimated Enrollment

1000

Start Date

June 7, 1997



Eligibility Criteria

        -  INCLUSION CRITERIA:

        Participants must meet at least one of these criteria:

        Have suspected or known disorder of the immune system or cancer

        Be a known or potential carrier of autoimmune disorder or immunodeficiency disease.
        Specific disorders may include but are not limited to:

          -  X-linked (severe combined immunodeficiency)

          -  Autosomal recessive SCID

          -  X-linked CD40 ligand deficiency

          -  Common variable immunodeficiency

          -  Ataxia-telangiectasia

          -  Wiskott Aldrich syndrome

          -  DiGeorge syndrome

          -  Infection with HTLV-1

        Age greater than or equal to 18 years.

        Participant must be able to understand and sign informed consent.

        Participants who will undergo apheresis must have hematocrit greater than 28%, and platelet
        count greater than 50,000.

        Subjects for whom apheresis is desired but whose counts are lower than those above must be
        evaluated and approved by a Department of Transfusion Medicine consult physician.

        Weight greater than 25 kg is necessary for apheresis.

        EXCLUSION CRITERIA:

        Overall Exclusion Criteria:

        Pregnant women will not be eligible for any aspect of this protocol.

        Exclusion Criteria for Apheresis Alone:

        Any diagnosed medical condition which may be worsened by the apheresis procedure.
        Specifically the participant should not have any of the following:

          1. Congestive Heart Failure

          2. History of angina

          3. Severe hypotension (at the discretion of the participant's physician, the apheresis
             staff and the attending physician from the Department of Transfusion Medicine (DTM)
             per DTM Standard Operating Policies.)

          4. Poorly controlled hypertension (average baseline blood pressure greater than 160/90)

          5. History of a coagulation protein disorder.

        Pediatric patients (less than 18 years) will not undergo apheresis.
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

Thomas A Waldmann, M.D., (240) 760-6050, [email protected]

Location Countries

United States

Location Countries

United States

Administrative Informations


NCT ID

NCT00001582

Organization ID

970143

Secondary IDs

97-C-0143

Responsible Party

Sponsor

Study Sponsor

National Cancer Institute (NCI)


Study Sponsor

Thomas A Waldmann, M.D., Principal Investigator, National Cancer Institute (NCI)


Verification Date

March 23, 2021