Genetic and Molecular Characteristics of Mexican Adults With Acute Myeloid Leukemia: a Prospective Multicentric Study.
Genetic and Molecular Characteristics of Mexican Adults With Acute Myeloid Leukemia: a Prospective Multicenter Study
Newly diagnosed adults patients with Acute Myeloid Leukemia will be assessed as traditionally by the treating institution using classic clinical, demographic and cytogenetic variables. Complementary molecular tests will be performed in the patients included in the study using PCR to detect classic CBF (Core Binding Factor) rearrangements: CBFB-MYH11 [inv(16)(p13;q22), isoforms A, E and D; AML-ETO (RUNX1-RUNX1T1) (t8;21)(q22;q22). NGS (Next Generation Sequencing) to detect mutations in: FLT3-ITD and TKD, NPM1, CEBPA, RUNX1, TP53, ASXL1, IDH1, IDH2 and KIT
Observational [Patient Registry]
Acute Myeloid Leukemia
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
March 22, 2020
October 31, 2025
Primary Completion Date
September 30, 2025
Inclusion Criteria: - Newly diagnosed AML - Over 15 years of age - Flow cytometry confirmation - Candidate for treatment (intensive or not intensive) Exclusion Criteria: - Acute Promyelocytic Leukemia - Mixed phenotype leukemias - Isolated myeloid sarcoma - Blastic plasmacytoid dendritic cell neoplasm
15 Years - N/A
Accepts Healthy Volunteers
, +521555487 0900, [email protected]
Mexican Agrupation for Hematology Study
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran