G-CSF in the Treatment of Toxic Epidermal Necrolysis

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Brief Title

G-CSF in the Treatment of Toxic Epidermal Necrolysis

Official Title

Evaluation of G-CSF as a Treatment of Toxic Epidermal Necrolysis

Brief Summary

      NeupoNET aims to evaluate interest of G-CSF in the treatment of Toxic Epidermal necrolysis.
      This is a prospective randomized controlled trial.

      Patients will be allocated in a treatment group (receiving an injection of 5 microg/kg/d of
      G-CSF during 5 consecutive days) or in a placebo group. Patients will be randomized at
      admission and will be followed until 3 months after discharge.

Study Phase

Phase 4

Study Type


Primary Outcome

Time for healing

Secondary Outcome

 Biological data: WBC count


Stevens - Johnson Syndrome


recombinant granulocyte - colony stimulating factor

Study Arms / Comparison Groups

Description:  An intravenous dose of 5 microg/kg of G-CSF (Neupogen) will be administered daily, from admission (day 0) to day 4.


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status


Estimated Enrollment


Start Date

July 2016

Completion Date

July 2022

Primary Completion Date

July 2022

Eligibility Criteria

        Inclusion Criteria:

          -  Toxic epidermal necrolysis with SCORTEN 1 to 5 at admission

        Exclusion Criteria:

          -  Toxic epidermal necrolysis with SCORTEN 6 or 7 at admission

          -  Hypercoagulable state

          -  Cardiac or peripheral arterial disease

          -  Active malignancy

          -  Myelodysplastic syndrome or hematological malignancy

          -  Fructose intolerance

          -  Pregnancy

          -  Patient refusal




18 Years - N/A

Accepts Healthy Volunteers



, , [email protected]

Location Countries


Location Countries


Administrative Informations



Organization ID


Responsible Party

Principal Investigator

Study Sponsor

University of Liege

Study Sponsor

, , 

Verification Date

November 2020