Evaluation of the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis

Brief Title

Evaluation of the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis

Official Title

Prospective Pilot Study Evaluating the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis

Brief Summary

      Infectious endocarditis (IE) is a serious condition with an annual incidence of 3 to 10 per
      100,000 people. Brain infarctions complicate approximately 20-40% of endocarditis.

      Brain MRI can detect the presence of recent ischemic lesions and asymptomatic microbleeds.
      Preoperative brain imaging is part of the recommended assessment in the management of IEs,
      but the type of imaging and sequences are not codified and the impact of cerebral and
      vascular imaging findings on the therapeutic decision remains uncertain.

      The level of evidence of the recommendations remains low, especially for complicated IEs of
      stroke. There is very little neurological clinical data on patients with IEs. Similarly,
      neurologists do not systematically participate in multidisciplinary meetings during the
      management of an IE. It therefore seems interesting to carry out a neurological cohort of
      this population and to evaluate what would be the contribution of vascular neurologists in
      the management of infectious endocarditis.
    



Study Type

Interventional


Primary Outcome

Medical care modification

Secondary Outcome

 The description of the preoperative neurological impairment

Condition

Endocarditis

Intervention

Neurological assessment

Study Arms / Comparison Groups

 Neurological cohort
Description:  All patients included in the study wil have a neurological examination

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Other

Estimated Enrollment

110

Start Date

July 2022

Completion Date

October 2024

Primary Completion Date

October 2024

Eligibility Criteria

        Inclusion Criteria:

          -  Adult patients

          -  Certain infectious endocarditis according to Dukes Criteria

          -  Signed informed consent

        Exclusion Criteria:

          -  Hospital admission due to neurovascular emergency

          -  MRI contraindications

          -  Pregnant or women of childbearing age who were not using contraception (oral
             diagnosis),

          -  Patient without health coverage,

          -  Patient under legal protection.
      

Gender

All

Ages

18 Years - N/A

Accepts Healthy Volunteers

No

Contacts

, 04 72 35 78 18, [email protected]

Location Countries

France

Location Countries

France

Administrative Informations


NCT ID

NCT05378126

Organization ID

69HCL18_0798


Responsible Party

Sponsor

Study Sponsor

Hospices Civils de Lyon


Study Sponsor

, , 


Verification Date

May 2022