Brief Title
Evaluation of the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis
Official Title
Prospective Pilot Study Evaluating the Prognostic Impact of a Neuro-vascular Examination Associated With Cerebral MRI in the Acute Phase of Infectious Endocarditis
Brief Summary
Infectious endocarditis (IE) is a serious condition with an annual incidence of 3 to 10 per
100,000 people. Brain infarctions complicate approximately 20-40% of endocarditis.
Brain MRI can detect the presence of recent ischemic lesions and asymptomatic microbleeds.
Preoperative brain imaging is part of the recommended assessment in the management of IEs,
but the type of imaging and sequences are not codified and the impact of cerebral and
vascular imaging findings on the therapeutic decision remains uncertain.
The level of evidence of the recommendations remains low, especially for complicated IEs of
stroke. There is very little neurological clinical data on patients with IEs. Similarly,
neurologists do not systematically participate in multidisciplinary meetings during the
management of an IE. It therefore seems interesting to carry out a neurological cohort of
this population and to evaluate what would be the contribution of vascular neurologists in
the management of infectious endocarditis.
Study Type
Interventional
Primary Outcome
Medical care modification
Secondary Outcome
The description of the preoperative neurological impairment
Condition
Endocarditis
Intervention
Neurological assessment
Study Arms / Comparison Groups
Neurological cohort
Description: All patients included in the study wil have a neurological examination
Publications
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Recruitment Information
Recruitment Status
Other
Estimated Enrollment
110
Start Date
July 2022
Completion Date
October 2024
Primary Completion Date
October 2024
Eligibility Criteria
Inclusion Criteria:
- Adult patients
- Certain infectious endocarditis according to Dukes Criteria
- Signed informed consent
Exclusion Criteria:
- Hospital admission due to neurovascular emergency
- MRI contraindications
- Pregnant or women of childbearing age who were not using contraception (oral
diagnosis),
- Patient without health coverage,
- Patient under legal protection.
Gender
All
Ages
18 Years - N/A
Accepts Healthy Volunteers
No
Contacts
, 04 72 35 78 18, [email protected]
Location Countries
France
Location Countries
France
Administrative Informations
NCT ID
NCT05378126
Organization ID
69HCL18_0798
Responsible Party
Sponsor
Study Sponsor
Hospices Civils de Lyon
Study Sponsor
, ,
Verification Date
May 2022