Etiology of Community Acquired Pneumonia

Brief Title

Etiology of Community Acquired Pneumonia

Official Title

Etiology of Community Acquired Pneumonia

Brief Summary

      The proposed study aims to provide current information, etiology and outcome of
      community-acquired pneumonia (CAP), risk factors for for CAP in isolates of Streptococcus
      pneumoniae and Haemophilus influencae, Mycoplasma pneumoniae, chlamydia pneumoniae and
      Legionella. Risk factors, including patient demographics, comorbid illnesses, setting of
      presentation, causative organisms, antibiotic history, and resistance profiles will be
      assessed and outcome will be recorded.

Detailed Description

      The following information will be collected: age, sex, occupation, hospital location at the
      time of positive culture (ER, medical ward, ICU etc), date of positive culture, prior
      hospitalization, receipt of outpatient dialysis, home care or other regular medical care (eg,
      outpatient chemotherapy), presence of invasive devices, receipt of antibiotics, including
      their type and whether they were adequate for the resistance profile of the organism, prior
      positive microbiologic cultures, time and location of positive cultures, underlying diseases
      and severity of illness, co-morbid illnesses, presence of urinary or intravascular devices,
      recent immunomodulative therapies or radiation therapy, physical exam findings, laboratory
      and radiographical data, antimicrobial usage within 30 days of onset of the infection,
      microbiological data and resistance patterns, choice of antibiotics once organism identified,
      bacteriological outcomes, laboratory results, demographic information, medications, clinical
      outcome,gender, height, weight, ethnicity, and past medical history. We will collect
      information retrospectively.

Study Type



Streptococcus Pneumonia


* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Estimated Enrollment


Start Date

May 2007

Completion Date

June 2017

Primary Completion Date

June 2017

Eligibility Criteria

        Inclusion Criteria:

          -  All patients with Streptococcus pneumoniae, Haemophilus influencae, Mycoplasma
             pneumoniae, chlamydia pneumoniae and Legionella species infections during the time
             period the study will be reviewed. A community-associated pneumonia isolate will be
             defined as one which was recovered from a clinical culture from a patient at UPMC who
             had no established risk factors for infection with an antibiotic resistant organism.
             Established risk factors are defined as: Isolation of the organism two or more days
             after admission for hospitalization OR history of hospitalization, surgery, dialysis,
             or residence in a long-term care facility within one year before the culture date OR
             The presence of an indwelling catheter or percutaneous medical device (eg,
             tracheostomy tube, gastrostomy tube, or Foley catheter) at the time of the culture OR
             Previous isolation of an antibiotic resistant organism.

        Exclusion Criteria:

          -  Does not meet entry criteria




18 Years - N/A

Accepts Healthy Volunteers



David L Paterson, MD, , 

Location Countries

United States

Location Countries

United States

Administrative Informations



Organization ID


Responsible Party


Study Sponsor

University of Pittsburgh

Study Sponsor

David L Paterson, MD, Principal Investigator, University of Pittsburgh/University of Pittsburgh Medical Center

Verification Date

June 2018