Efficacy of Topical Cysteamine in Nephropathic Cyctinosis
The aim of this study is to evaluate the efficacy of topical cysteamine eye drops in the
treatment of corneal cystine crystals deposits in patients with nephropathic cystinosis.
A total of 26 patients with nephropathic cystinosis were included in this prospective study.
Patients were evaluated for improvement of corneal cysteine deposits crystals and photophobia
following treatment with topical 0.55% cysteamine eye drops.
Number of participants with improvement of photophobia, corneal cystine crystals and visual acuity following treatment with topical cysteamine 0.55% eye drops in patients with nephropathic cystinosis.
Study Arms / Comparison Groups
cysteamine eye drops
Description: Patients used cysteamine eye drops every 2 hours while awake to both eyes.
* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.
Primary Completion Date
- patients with confirmed diagnosis of nephropathic cystinosis
- leucocyte cystine concentration level of more than 2.0 nmol half-cystine/ mg protein
- clinical evidence of tissue deposition of cystine and tissue damage due to cystinosis
- Allergy to cysteamine
8 Months - 19 Years
Accepts Healthy Volunteers
The Eye Center and The Eye Foundation for Research in Ophthalmology