Efficacy of Topical Cysteamine in Nephropathic Cyctinosis

Brief Title

Efficacy of Topical Cysteamine in Nephropathic Cyctinosis


Brief Summary

      The aim of this study is to evaluate the efficacy of topical cysteamine eye drops in the
      treatment of corneal cystine crystals deposits in patients with nephropathic cystinosis.
    

Detailed Description

      A total of 26 patients with nephropathic cystinosis were included in this prospective study.
      Patients were evaluated for improvement of corneal cysteine deposits crystals and photophobia
      following treatment with topical 0.55% cysteamine eye drops.
    


Study Type

Interventional


Primary Outcome

Number of participants with improvement of photophobia, corneal cystine crystals and visual acuity following treatment with topical cysteamine 0.55% eye drops in patients with nephropathic cystinosis.


Condition

Nephropathic Cyctinosis

Intervention

Cysteamine

Study Arms / Comparison Groups

 cysteamine eye drops
Description:  Patients used cysteamine eye drops every 2 hours while awake to both eyes.

Publications

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information


Recruitment Status

Drug

Estimated Enrollment

26

Start Date

January 2004

Completion Date

March 2016

Primary Completion Date

December 2012

Eligibility Criteria

        Inclusion Criteria:

          -  patients with confirmed diagnosis of nephropathic cystinosis

          -  leucocyte cystine concentration level of more than 2.0 nmol half-cystine/ mg protein

          -  clinical evidence of tissue deposition of cystine and tissue damage due to cystinosis

        Exclusion Criteria:

          -  Allergy to cysteamine
      

Gender

All

Ages

8 Months - 19 Years

Accepts Healthy Volunteers

No

Contacts

, , 



Administrative Informations


NCT ID

NCT02766855

Organization ID

TEC C123


Responsible Party

Principal Investigator

Study Sponsor

The Eye Center and The Eye Foundation for Research in Ophthalmology


Study Sponsor

, , 


Verification Date

May 2016