Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome

Brief Title

Dynamic Profiles of Cytokine/Chemokine in Severe Acute Respiratory Syndrome

Brief Summary

      Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel
      coronavirus (SARS-CoV). The major clinical features of SARS include fever, dyspnea,
      lymphopenia, and a rapid progression of pulmonary infiltrates on chest radiologic images. The
      SARS-related deaths have resulted mainly from pulmonary complications, including progressive
      respiratory failure due to alveolar damage and acute respiratory distress syndrome (ARDS).
      Pathological changes in SARS suggest that SARS sequelae such as infiltration of PMN in lung
      tissue, multiple organ dysfunction and ARDS have been associated with cytokines and chemokine
      dysregulation. Some patients still manifested lung injury at a time when the viral load was
      falling also supports the immune nature of the lung damage. We therefore undertook an
      analysis of dynamic production of cytokine/chemokines in SARS patients with an initial normal
      chest radiograph in order to improve understanding of disease pathogenesis and improve
      patient management.

Study Type





* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Eligibility Criteria

        Inclusion Criteria:

          -  SARS group: Patients with SARS

        Exclusion Criteria:

          -  Hospital acquired pneumonia




20 Years - N/A


Jung-Yien Chien, MD, , 

Administrative Informations



Organization ID


Study Sponsor

National Taiwan University Hospital

Study Sponsor

Jung-Yien Chien, MD, Study Chair, NTUH

Verification Date

July 2004